Hepatitis B caused by a hepatitis B surface antigen escape mutant

被引：0
|
作者：
Eiji Kajiwara
Yasuhito Tanaka
Tomoko Ohashi
Kotarou Uchimura
Seizo Sadoshima
Mitsuru Kinjo
Masashi Mizokami
机构：
[1] Nippon Steel Yawata Memorial Hospital,Department of Gastroenterology, Internal Medicine and Pathology
[2] Nagoya City University Graduate School of Medical Sciences,Department of Clinical Molecular Informative Medicine
来源：
Journal of Gastroenterology | 2008年 / 43卷
关键词：
hepatitis B; determinant region; G145R escape mutant;
D O I：
暂无
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学科分类号：
摘要：
Amino acid substitutions within the S gene involving the major antigenic a determinant of the hepatitis B virus (HBV) surface antigen (HBsAg) have been detected in cases of failure of immunization against the virus. Our report showed development of clinical hepatitis in presence of antibody to HBsAg in a healthy individual. A single amino acid substitution (G145R) within the a determinant of the HBsAg was determined by sequencing of the isolated HBV strain. Lamivudine treatment efficiently cleared the peripheral HBV DNA, HBsAg, and hepatitis B e antigen. In conclusion, the immune escape mutant in the S gene can cause hepatitis despite pre-existing naturally acquired immunity.
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页码：243 / 247
页数：4
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