Hepatitis B caused by a hepatitis B surface antigen escape mutant

被引：21
|
作者：
Kajiwara, Eiji [1 ]
Tanaka, Yasuhito [2 ]
Ohashi, Tomoko [1 ]
Uchimura, Kotarou [1 ]
Sadoshima, Seizo [1 ]
Kinjo, Mitsuru [1 ]
Mizokami, Masashi [2 ]
机构：
[1] Nippon Steel Yawata Mem Hosp, Dept Gastroenterol Internal Med & Pathol, Yahatahigashi Ku, Kitakyushu, Fukuoka 8058508, Japan
[2] Nagoya City Univ, Grad Sch Med Sci, Dept Clin Mol Informat Med, Nagoya, Aichi, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2008年 / 43卷 / 03期
关键词：
hepatitis B; a determinant region; G145R escape mutant;
D O I：
10.1007/s00535-007-2150-9
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Amino acid substitutions within the S gene involving the major antigenic a determinant of the hepatitis B virus (HBV) surface antigen (HBsAg) have been detected in cases of failure of immunization against the virus. Our report showed development of clinical hepatitis in presence of antibody to HBsAg in a healthy individual. A single amino acid substitution (G145R) within the a determinant of the HBsAg was determined by sequencing of the isolated HBV strain. Lamivudine treatment efficiently cleared the peripheral HBV DNA, HBsAg, and hepatitis B e antigen. In conclusion, the immune escape mutant in the S gene can cause hepatitis despite pre-existing naturally acquired immunity.
引用
收藏
页码：243 / 247
页数：5
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