Leber's hereditary optic neuropathy mutations in ethambutol-induced optic neuropathy

被引：0
|
作者：
Jeong-Min Hwang
Jiyeon Kim
Sung Sup Park
机构：
[1] Department of Ophthalmology,
[2] Seoul Municipal Boramae Hospital,undefined
[3] College of Medicine,undefined
[4] Seoul National University,undefined
[5] 395,undefined
[6] Sindaebang–2-dong,undefined
[7] Dongjak-ku,undefined
[8] Seoul 156–707,undefined
[9] Korea. hjm@snu.ac.kr,undefined
[10] Department of Clinical Pathology,undefined
[11] Seoul National University College of Medicine,undefined
来源：
Journal of Neurology | 2003年 / 250卷
关键词：
Key words Leber's hereditary optic neuropathy; mitochondrial DNA mutation; toxic optic neuropathy; ethambutol;
D O I：
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中图分类号：
学科分类号：
摘要：
Primary mitochondrial DNA (mtDNA) mutation at the nt 11778 site in Leber's hereditary optic neuropathy (LHON) has been reported to be present in patients with ethambutol-induced optic neuropathy. To study further this association between LHON and ethambutol-induced optic neuropathy, we tested ethambutol-induced optic neuropathy patients for the presence of the mtDNA mutations at nucleotides (nt)–11778, nt–14484, nt–3460, nt–15257, nt–9438, nt–9804, nt–13730, and nt–14459 in 24, 15, 8, 6, 5, 5, 5, and 5 patients respectively. However, none of the ethambutol-induced optic neuropathy patients was found to exhibit any pathogenic LHON mtDNA mutation. In conclusion, we found no evidence of any association between ethambutol-induced optic neuropathy and the LHON mutations.
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页码：87 / 89
页数：2
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