Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing

被引：0

作者：

Hongzhen Zhang

Ronghua Xu

Zuowen Yin

Jun Yu

Ning Liang

Qian Geng

机构：

[1] Huazhong University of Science and Technology Union Shenzhen Hospital,Gastrointestinal surgery

[2] The Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University,Department of Dermatology

[3] Huazhong University of Science and Technology Union Shenzhen Hospital,Emergency department

来源：

Macromolecular Research | 2022年 / 30卷

关键词：

drug-loading; chondroitin sulfate; microspheres; microfluidic electrospray; wound healing;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drug-loaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.

引用

页码：36 / 42

页数：6

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