Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease

被引:0
|
作者
Martina Svensson
Emelie Andersson
Oscar Manouchehrian
Yiyi Yang
Tomas Deierborg
机构
[1] Lund University,Experimental Neuroinflammation Laboratory, Department of Experimental Medical Sciences
[2] BMC B11,undefined
来源
Scientific Reports | / 10卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Physical exercise has been suggested to reduce the risk of developing Alzheimer’s disease (AD) as well as ameliorate the progression of the disease. However, we recently published results from two large epidemiological studies showing no such beneficial effects on the development of AD. In addition, long-term, voluntary running in the 5xFAD mouse model of AD did not affect levels of soluble amyloid beta (Aβ), synaptic proteins or cognitive function. In this follow-up study, we investigate whether running could impact other pathological aspects of the disease, such as insoluble Aβ levels, the neuroinflammatory response and non-cognitive behavioral impairments. We investigated the effects of 24 weeks of voluntary wheel running in female 5xFAD mice (n = 30) starting at 2–3 months of age, before substantial extracellular plaque formation. Running mice developed hindlimb clasping earlier (p = 0.009) compared to sedentary controls. Further, running exacerbated the exploratory behavior in Elevated plus maze (p = 0.001) and anxiety in Open field (p = 0.024) tests. Additionally, microglia, cytokines and insoluble Aβ levels were not affected. Taken together, our findings suggest that voluntary wheel running is not a beneficial intervention to halt disease progression in 5xFAD mice.
引用
收藏
相关论文
共 50 条
  • [21] Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
    Ioannis Dafnis
    Christina Mountaki
    Eleni Fanarioti
    Dimitrios C. Mastellos
    Michalis Karvelas
    Vaios T. Karathanos
    Athina Tzinia
    Catherine R. Dermon
    Angeliki Chroni
    Molecular Neurobiology, 2022, 59 : 7303 - 7322
  • [22] Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer’s Disease
    Wei Zhen
    Chen Xiao-Chun
    Song Yue
    Pan Xiao-Dong
    Dai Xiao-Man
    Zhang Jing
    Cui Xiao-Li
    Wu Xi-Lin
    Zhu Yuan-Gui
    中华医学杂志英文版, 2016, 129 (15)
  • [23] Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease
    Girard, Stephane D.
    Baranger, Kevin
    Gauthier, Cyrielle
    Jacquet, Marlyse
    Bernard, Anne
    Escoffier, Guy
    Marchetti, Evelyne
    Khrestchatisky, Michel
    Rivera, Santiago
    Roman, Francois S.
    JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 (03) : 781 - 796
  • [24] Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease
    Jullienne, Amandine
    Szu, Jenny I. I.
    Quan, Ryan
    Trinh, Michelle V. V.
    Norouzi, Tannoz
    Noarbe, Brenda P. P.
    Bedwell, Amanda A. A.
    Eldridge, Kierra
    Persohn, Scott C. C.
    Territo, Paul R. R.
    Obenaus, Andre
    FRONTIERS IN AGING NEUROSCIENCE, 2023, 15
  • [25] Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer's Disease
    Dunham, Sage J. B.
    McNair, Katelyn A.
    Adams, Eric D.
    Avelar-Barragan, Julio
    Forner, Stefania
    Mapstone, Mark
    Whiteson, Katrine L.
    MBIO, 2022, 13 (06):
  • [26] Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease
    Lim, Jeremiah K. H.
    Li, Qiao-Xin
    He, Zheng
    Vingrys, Algis J.
    Chinnery, Holly R.
    Mullen, Jamie
    Bui, Bang V.
    Nguyen, Christine T. O.
    FRONTIERS IN NEUROSCIENCE, 2020, 14
  • [27] Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease
    Wright, Alexa L.
    Weible, Aldis P.
    Estes, Olivia B.
    Wehr, Michael
    FRONTIERS IN AGING NEUROSCIENCE, 2025, 17
  • [28] Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease
    Wei, Zhen
    Chen, Xiao-Chun
    Song, Yue
    Pan, Xiao-Dong
    Dai, Xiao-Man
    Zhang, Jing
    Cui, Xiao-Li
    Wu, Xi-Lin
    Zhu, Yuan-Gui
    CHINESE MEDICAL JOURNAL, 2016, 129 (15) : 1835 - 1844
  • [29] Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer's Disease
    Matei, Nathanael
    Leahy, Sophie
    Blair, Norman P.
    Burford, James
    Rahimi, Mansour
    Shahidi, Mahnaz
    CELLS, 2022, 11 (15)
  • [30] Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer's Disease
    Matei, Nathanael
    Leahy, Sophie
    Blair, Norman
    Burford, James
    Shahidi, Mahnaz
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2021, 62 (08)