Freezing of gait in Parkinson’s disease: gray and white matter abnormalities

被引:0
|
作者
Sara Pietracupa
Antonio Suppa
Neeraj Upadhyay
Costanza Giannì
Giovanni Grillea
Giorgio Leodori
Nicola Modugno
Francesca Di Biasio
Alessandro Zampogna
Claudio Colonnese
Alfredo Berardelli
Patrizia Pantano
机构
[1] IRCCS Neuromed Institute,Department of Neurology and Psychiatry
[2] Sapienza University of Rome,undefined
来源
Journal of Neurology | 2018年 / 265卷
关键词
Parkinson's disease; Freezing of gait; Magnetic resonance imaging; Cortical thickness; Diffusion tensor imaging;
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中图分类号
学科分类号
摘要
Freezing of gait (FOG) is a disabling disorder that often affects Parkinson’s disease (PD) patients in advanced stages of the disease. To study structural gray matter (GM) and white matter (WM) changes in PD patients with and without FOG, twenty-one PD patients with FOG (PD-FOG), 16 PD patients without FOG (PD-nFOG) and 19 healthy subjects (HS) underwent a standardized MRI protocol. For the gray matter evaluation, cortical volume (CV), cortical thickness (CTh), and surface area (SA) were analyzed using the FreeSurfer pipeline. For the white matter evaluation, DTI images were analyzed using tracts constrained by underlying anatomy (TRACULA) toolbox in FreeSurfer. PD-FOG patients exhibited lower CTh than HS in the mesial surface of both cerebral hemispheres, including the superior frontal gyrus, paracentral lobule, posterior cingulate cortex, precuneus and pericalcarine cortex, and in the right dorsolateral prefrontal cortex. Moreover, significant WM changes were observed in PD-FOG patients in comparison with HS in the superior longitudinal fasciculus, uncinate fasciculus, cingulum cingulate gyrus and inferior longitudinal fasciculus (prevalently in the right hemisphere) and in the frontal radiations of the corpus callosum. DTI abnormalities in specific WM bundles correlated significantly with cognitive measures. The damage of multiple cortical areas involved in high-level gait control together with WM disruption between motor, cognitive and limbic structures may represent the anatomical correlate of FOG.
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页码:52 / 62
页数:10
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