Silicone breast implant modification review: Overcoming capsular contracture

被引：57
|
作者：
Shin B.H. [1 ]
Kim B.H. [1 ]
Kim S. [2 ]
Lee K. [2 ,7 ]
Choy Y.B. [1 ,3 ,6 ]
Heo C.Y. [3 ,4 ,5 ]
机构：
[1] Seoul National University College of Medicine, Department of Biomedical Engineering, Seoul
[2] Seoul National University, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul
[3] Seoul National University, Interdisciplinary Program for Bioengineering, College of Engineering, Seoul
[4] Seoul National University, Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul
[5] Seoul National University Bundang Hospital, Department of Plastic and Reconstructive Surgery, Seongnam
[6] Seoul National University, Institute of Medical and Biological Engineering, Medical Research Center, Seoul
[7] Advanced Institutes of Convergence Technology, Suwon, Gyeonggi-do
来源：
Biomaterials Research | / 22卷 / 1期
基金：
新加坡国家研究基金会;
关键词：
Capsular contracture; Fibrosis; Foreign body reaction; Inflammation; Modification; Silicone implant;
D O I：
10.1186/s40824-018-0147-5
中图分类号：
学科分类号：
摘要：
Background: Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. This review summarizes and explores these trends. Main body: First, we examined the overall foreign body response from initial inflammation to fibrosis capsule formation in detail and introduced various studies to overcome capsular contracture. Secondly, we introduced that the main research approaches are to inhibit fibrosis with anti-inflammatory drugs or antibiotics, to control the topography of the surface of silicone implants, and to administer plasma treatment. Each study examined aspects of the various mechanisms by which capsular contracture could occur, and addressed the effects of inhibiting fibrosis. Conclusion: This review introduces various silicone surface modification methods to date and examines their limitations. This review will help identify new directions in inhibiting the fibrosis of silicone implants. © 2018 The Author(s).
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