Integrase Strand Transfer Inhibitors in HIV Therapy

被引：15
|
作者：
Mesplède T. [1 ]
Wainberg M.A. [1 ,2 ,3 ]
机构：
[1] McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC
[2] Division of Experimental Medicine, McGill University, Montréal, QC
[3] Department of Microbiology and Immunology, McGill University, Montréal, QC
来源：
Infectious Diseases and Therapy | 2013年 / 2卷 / 2期
关键词：
Dolutegravir; Elvitegravir; HIV; Infectious disease; Integrase inhibitors; Raltegravir; Resistance; Sequencing;
D O I：
10.1007/s40121-013-0020-8
中图分类号：
学科分类号：
摘要：
HIV drug resistance has been one of the major obstacles to HIV eradication and has contributed to the need for the constant development of new antiretroviral drugs over the past 25 years. With the recent approval of dolutegravir for human therapy by the U.S. Food and Drug Administration, health practitioners may soon have access to three integrase strand transfer inhibitors to treat individuals living with HIV. Here, we review the use of raltegravir, elvitegravir, and dolutegravir for use in first- and second-line HIV treatment regimens and the issue of HIV resistance against integrase inhibitors. © 2013 The Author(s).
引用
收藏
页码：83 / 93
页数：10
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