Mechanisms of Disease: sodium channels and neuroprotection in multiple sclerosis—current status

被引：0
|
作者：
Stephen G Waxman
机构：
[1] SG Waxman is the Bridget Flaherty Professor of Neurology,
[2] Neurobiology and Pharmacology at Yale Medical School,undefined
[3] New Haven,undefined
[4] CT,undefined
[5] and Director of the Center for Neuroscience and Regeneration Research,undefined
[6] VA Connecticut Healthcare,undefined
[7] West Haven,undefined
[8] CT,undefined
[9] USA.,undefined
来源：
Nature Clinical Practice Neurology | 2008年 / 4卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
Axon degeneration is a major contributor to disability in multiple sclerosis, and sodium channels have been shown to have a crucial role in this process. In this article, Waxman reviews the development of the concept of sodium channel blockers as neuroprotectants in multiple sclerosis, and discusses recent attempts to translate this approach from the laboratory to the clinic.
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页码：159 / 169
页数：10
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