Practical considerations for pharmaceutical antibody production in different crop systems

被引：0
|
作者：
Eva Stoger
Markus Sack
Yolande Perrin
Carmen Vaquero
Esperanza Torres
Richard M. Twyman
Paul Christou
Rainer Fischer
机构：
[1] IUCT,Fraunhofer Department for Molecular Biotechnology
[2] Grafschaft,Institute for Biology I
[3] RWTH Aachen,undefined
[4] Univ. de Compiegne,undefined
[5] Sainsbury Laboratory,undefined
来源：
Molecular Breeding | 2002年 / 9卷
关键词：
Cereals; KDEL; Molecular farming; Pharmaceutical antibodies; Plantibodies; Recombinant proteins; scFv; Tobacco; Transgenic crops;
D O I：
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中图分类号：
学科分类号：
摘要：
The potential of plant cells to produce functional recombinantantibodies has been demonstrated in a number of different plant systems. Wepresent a comparative study of a well-defined target protein, a single chain Fvantibody, in different transgenic crop species and cultured tissues. The effectof different regulatory elements and signals for subcellular targeting areconsidered. Practical considerations for the choice of a particular cropsystem,such as yield, storage, distribution and containment properties are discussed.
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页码：149 / 158
页数：9
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