Itaconate trims the fat

被引：0
|
作者：
Rory Turner
Thekla Cordes
Martina Wallace
机构：
[1] University College Dublin,Institute of Food and Health, School of Agriculture and Food Science, Conway Institute of Biomolecular and Biomedical Research
[2] Technische Universität Braunschweig,Department of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS)
[3] Helmholtz Centre for Infection Research,Cellular Metabolism in Infection
来源：
Nature Metabolism | 2023年 / 5卷
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学科分类号：
摘要：
Inflammation is characterized by cell metabolic reprogramming that can influence the outcome of metabolic syndrome-related diseases such as non-alcoholic fatty liver disease (NAFLD). In this issue, Weiss et al. discover that preventing the production of the immunomodulatory metabolite itaconate increases liver fat accumulation in mouse models of NAFLD and that treatment with itaconate may promote fat oxidation. This study reveals new therapeutic potential for targeting the itaconate metabolic pathway in NAFLD.
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页码：915 / 916
页数：1
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