Immunoadsorption for treatment of dilated cardiomyopathy [Immunadsorption als therapieverfahren der dilatativen kardiomyopathie]

被引：0
|
作者：
Felix S.B. [1 ,2 ]
Dörr M. [1 ]
Herda L.R. [1 ]
Beug D. [1 ]
Staudt A. [1 ]
机构：
[1] Klinik und Poliklinik für Innere Medizin B, Ernst-Moritz-Arndt-Universität Greifswald, 17475 Greifswald
来源：
Der Internist | 2008年 / 49卷 / 1期
关键词：
Cardiac antibodies; Dilated cardiomyopathy; Humoral immune system; Immunoadsorption; Myocardial inflammation;
D O I：
10.1007/s00108-007-1991-x
中图分类号：
学科分类号：
摘要：
Abnormalities of the cellular and humoral immune system have been described in patients with dilated cardiomyopathy (DCM). For patients with DCM, immunochemical analyses of myocardial biopsies have demonstrated myocardial inflammation. Various circulating cardiac antibodies have been detected among DCM patients. Circulating antibodies are extractable by immunoadsorption. Recent open controlled pilot studies showed that removal of antibodies by immunoadsorption induces improvement of cardiac function in DCM. Furthermore, it decreases myocardial inflammation. This may offer a new therapeutic option for patients with severe heart failure due to dilated cardiomyopathy. © 2007 Springer Medizin Verlag.
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页码：51 / 56
页数：5
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