Association between polymorphisms in candidate genes and morbid obesity

被引：0
|
作者：
D Evans
AM Wolf
U Nellessen
S Ahle
B Kortner
HW Kuhlmann
U Beisiegel
机构：
[1] Medizinische Klinik,
[2] Universitätskrankenhaus Eppendorf,undefined
[3] Klinik für Allgemeinchirurgie,undefined
[4] Evangelisches und Johanniter Klinikum,undefined
来源：
International Journal of Obesity | 2001年 / 25卷
关键词：
morbid obesity; polymorphisms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Polymorphisms in a number of candidate genes have been reported to be associated with obesity. We have determined the incidence of the following polymorphisms in the following candidate genes in a group of 388 morbid obese patients (mean body mass index (BMI) 52±8.01) who underwent gastric banding surgery: lipoprotein lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor γ (PPARγ), P12A, P115Q and c1431t; peroxisome proliferator receptor α (PPARα) L162V; β-adrenergic receptor 2 (β-AR 2), Q27E; β-adrenergic receptor 3 (β-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp insertion. Only for the ucp2 polymorphism did we find a statistically significant association with obesity. The β-AR 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of obesity and may act synergistically.
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页码：S19 / S21
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