Effect of compound GB-115 on morphine-induced analgesia

被引：0
|
作者：
L. G. Kolik
V. N. Zhukov
S. B. Seredenin
机构：
[1] Russian Academy of Medical Sciences,Department of Pharmacogenetics, V. V. Zakusov Institute of Pharmacology
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 143卷
关键词：
antinociception; compound GB-115; morphine; naloxone; mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice. This potentiation of antinociceptive activity of morphine was probably related to the interaction of GB-115 with supraspinal opioidergic mechanisms.
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页码：703 / 705
页数：2
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