Quantifying the binding landscapes of protein–protein interactions

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作者：
Andrew J. Bissette
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[1] Communications Chemistry,
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Communications Chemistry | / 4卷
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摘要：
Small changes in protein structure can have pronounced effects on protein–protein interactions, but quantifying this has only recently become possible. Now, the binding landscapes of three homologous enzyme–inhibitor complexes are quantified and shown to depend on whether the inhibitor binds its natural target or a structurally similar protein.
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