The current research explored appraisals of the negative emotions that arise in the context of setbacks. We proposed that experiencing negative emotions could be appraised as either enhancing or debilitating. Across two studies, we investigated the hypotheses that individuals who perceive experiencing negative emotion to be enhancing, relative to debilitating, would report experiencing less severe negative emotions and engage in more mastery-oriented behavioral strategies after encountering setbacks. In Study 1 (N = 283), we examined initial associations among negative emotion appraisals, severity of emotions experienced, and behavioral strategies. In Study 2 (N = 141), in a preregistered report, we experimentally manipulated negative emotion appraisals to test causal relationships among these constructs. Results supported hypotheses in Study 1. In Study 2, we manipulated negative emotion appraisals but failed to shift self-regulatory processes.