Tumor-Infiltrating Lymphocytes in Breast Cancer. Association with Clinical and Pathological Parameters

被引：0
|
作者：
T. N. Zabotina
O. V. Korotkova
A. I. Chertkova
E. N. Zakharova
D. V. Tabakov
N. T. Dzhgamadze
M. V. Savostikova
E. V. Artamonova
V. A. Khailenko
E. I. Kovalenko
Z. G. Kadagidze
机构：
[1] N. N. Blokhin National Medical Research Center of Oncology,
[2] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
关键词：
breast cancer; Ki-67%; estrogen and progesterone receptors; tumor-infiltrating lymphocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In patients with primary resectable breast cancer, a positive correlation between the age and the count of CD16+ lymphocytes and a negative correlation of this parameter with the number of regulatory CD4+CD25+CD127— cells and proliferative activity of Ki-67 tumor cells were revealed. Higher level of Ki-67 was associated with reduced number of effector lymphocytes (CD8+ and CD16+) and elevated content of regulatory CD8+CD11b—CD28— T cells. The absence of expression of estrogen receptors was associated with reduced cytotoxic potential of CD8+ T cell in comparison with ER+ breast cancer. The percentage of CD8+ lymphocytes (CD3+CD8+ and CD8+CD11b+CD28+) among lymphocytes infiltrating the tumor was higher in PR+ breast cancer than in PR— tumors. With increasing the tumor load, the number of lymphocytes expressing CD16 marker and their cytotoxic potential decreased.
引用
收藏
页码：241 / 244
页数：3
相关论文
共 50 条
  • [1] Tumor-Infiltrating Lymphocytes in Breast Cancer. Association with Clinical and Pathological Parameters
    Zabotina, T. N.
    Korotkova, O. V.
    Chertkova, A. I.
    Zakharova, E. N.
    Tabakov, D. V.
    Dzhgamadze, N. T.
    Savostikova, M. V.
    Artamonova, E. V.
    Khailenko, V. A.
    Kovalenko, E. I.
    Kadagidze, Z. G.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 166 (02) : 241 - 244
  • [2] Clinical significance of tumor-infiltrating lymphocytes in breast cancer
    Stanton, Sasha E.
    Disis, Mary L.
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2016, 4
  • [3] Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice
    de Melo Gagliato, Debora
    Cortes, Javier
    Curigliano, Giuseppe
    Loi, Sherene
    Denkert, Carsten
    Perez-Garcia, Jose
    Holgado, Esther
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2017, 1868 (02): : 527 - 537
  • [4] Tumor-infiltrating lymphocytes/macrophages and clinical outcome in breast cancer
    Kim, Y-S.
    Kim, J-S.
    [J]. ANNALS OF ONCOLOGY, 2016, 27
  • [5] Relevance of tumor-infiltrating lymphocytes in breast cancer
    Sathana Dushyanthen
    Paul A. Beavis
    Peter Savas
    Zhi Ling Teo
    Chenhao Zhou
    Mariam Mansour
    Phillip K. Darcy
    Sherene Loi
    [J]. BMC Medicine, 13
  • [6] Relevance of tumor-infiltrating lymphocytes in breast cancer
    Dushyanthen, Sathana
    Beavis, Paul A.
    Savas, Peter
    Teo, Zhi Ling
    Zhou, Chenhao
    Mansour, Mariam
    Darcy, Phillip K.
    Loi, Sherene
    [J]. BMC MEDICINE, 2015, 13
  • [7] Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer
    Ahn, Sung Gwe
    Jeong, Joon
    Hong, Soon Won
    Jung, Woo Hee
    [J]. JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, 2015, 49 (05) : 355 - 363
  • [8] Tumor-infiltrating lymphocytes are an important pathological predictor for neoadjuvant chemotherapy in patients with breast cancer
    Yamaguchi, R.
    Tanaka, M.
    Yano, A.
    Yamaguchi, M.
    Yano, H.
    [J]. BREAST, 2011, 20 : S76 - S76
  • [9] Emerging measurements for tumor-infiltrating lymphocytes in breast cancer
    Wu, Rongrong
    Horimoto, Yoshiya
    Oshi, Masanori
    Benesch, Matthew G. K.
    Khoury, Thaer
    Takabe, Kazuaki
    Ishikawa, Takashi
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2024, 54 (06) : 620 - 629
  • [10] Tumor-infiltrating lymphocytes in triple negative breast cancer
    Zakhartseva, L. M.
    Yanovytska, M. O.
    [J]. PATHOLOGIA, 2020, (03): : 287 - 294
12345