Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice

被引:60
|
作者
de Melo Gagliato, Debora [1 ]
Cortes, Javier [2 ,8 ]
Curigliano, Giuseppe [3 ]
Loi, Sherene [4 ]
Denkert, Carsten [5 ,6 ]
Perez-Garcia, Jose [7 ]
Holgado, Esther [2 ,9 ]
机构
[1] Hosp Sirio Libanes, Adma Jafet St 91, BR-1308050 Sao Paulo, Brazil
[2] Ramon y Cajal Univ Hosp, Ctra Colmenar Viejo Km 9,100, Madrid 28034, Spain
[3] European Inst Oncol, Via Ripamonti 435, I-20146 Milan, Italy
[4] Univ Melbourne, Peter MacCallum Canc Ctr, Grattan St 305, Melbourne, Vic 3000, Australia
[5] Charite, Inst Pathol, Campus Mitre,Charitepl 1, D-10117 Berlin, Germany
[6] German Canc Consortium DKTK, Campus Mitre,Charitepl 1, D-10117 Berlin, Germany
[7] Quiron Hosp, Baselga Ontol Inst, Placa Alfonso Comin 5, Barcelona 08023, Spain
[8] Vall dHebron Inst Oncol, Ctr Cellex, Calle Natzaret 115-117, Barcelona 08035, Spain
[9] Baselga Inst Oncol, Madrid, Spain
来源
关键词
Breast Cancer; Immune system; Lymphocyte infiltration; Response to chemotherapy; RENAL-CELL CARCINOMA; GENE-EXPRESSION; PROGNOSTIC-SIGNIFICANCE; IMMUNE-SYSTEM; FREE SURVIVAL; RECEPTOR; IMMUNOTHERAPY; CHEMOTHERAPY; IDENTIFICATION; MODELS;
D O I
10.1016/j.bbcan.2017.10.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor size. It can be categorized based on the gene expression profile, which identifies the distinct molecular subtype. More recently, stromal tissue has been recognized as an important modulator of tumor cell growth, pathogenesis, and progression. Immune cells could drive important clinical characteristics that affect BC outcomes. Subgroups of patients who have tumor-infiltrating lymphocytes in the stroma may have better response to chemotherapy and favorable long-term prognosis. Accumulating evidence shows that the immune system plays a crucial role in the outcomes of some BC subgroups, especially more aggressive, proliferative ones such as triple-negative and HER2-positive BC. This review article will present data on the role of lymphocyte infiltration in BC prognosis and response to therapy. This review will also introduce the reader to the challenges of applying this promising prognostic and predictive biomarker in clinical practice.
引用
收藏
页码:527 / 537
页数:11
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