Association of estrogen receptor β (ESR2) gene polymorphism with blood pressure

被引：0
|
作者：
S. Ogawa
M. Emi
M. Shiraki
T. Hosoi
Y. Ouchi
S. Inoue
机构：
[1] Department of Geriatric Medicine,
[2] Graduate School of Medicine,undefined
[3] The University of Tokyo,undefined
[4] Tokyo,undefined
[5] Japan,undefined
[6] Department of Molecular Biology,undefined
[7] Institute of Gerontology,undefined
[8] Nippon Medical School,undefined
[9] 1-396 Kosugi-cho,undefined
[10] Nakahara-ku,undefined
[11] Kawasaki 211-8533,undefined
[12] Japan Tel. +81-44-733-5230; Fax +81-44-733-5192 e-mail: memi@nms.ac.jp,undefined
[13] Research Institute and Practice for Involutional Diseases,undefined
[14] Nagano,undefined
[15] Japan,undefined
[16] Tokyo Metropolitan Geriatric Hospital,undefined
[17] Tokyo,undefined
[18] Japan,undefined
来源：
Journal of Human Genetics | 2000年 / 45卷
关键词：
Key wordsESR2; ESR2 polymorphism; Systemic hypertension; Microsatellite marker; Allelic association;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the association between a dinucleotide (cytosine-adenine; CA) repeat polymorphism located in the flanking region of the human estrogen receptor β (ESR2) gene and systemic blood pressure in 187 healthy postmenopausal Japanese women. The genotype was classified as "A" through "O" according to the number of these repeats from 18 to 32. When we separated the subjects into two groups — bearing at least one “I” allele (26 CA repeats) and those who did not — we found that the former subjects had significantly higher systolic blood pressure than the latter (mean ± SD, 146.0 ± 25.0 vs 136.6 ± 23.4; P = 0.032). These data suggest that genetic variation at the ESR2 locus may be associated with some determinants of blood pressure, and that there is a possible involvement of this polymorphism in causing hypertension in Japanese women.
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页码：327 / 330
页数：3
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