Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

被引：0
|
作者：
Reiner Frey
Corina Becker
Sigrun Unger
Anja Schmidt
Georg Wensing
Wolfgang Mueck
机构：
[1] Clinical Pharmacology,
[2] Bayer Pharma AG,undefined
[3] Pharma Research Centre,undefined
[4] Global Biostatistics,undefined
[5] Bayer Pharma AG,undefined
[6] Pharma Research Centre,undefined
来源：
BMC Pharmacology and Toxicology | / 14卷 / Suppl 1期
关键词：
Pulmonary Hypertension; Liver Cirrhosis; Hepatic Impairment; Oral Tablet; Moderate Hepatic Impairment;
D O I：
10.1186/2050-6511-14-S1-P21
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Antihypertensive Effects of a Soluble Guanylate Cyclase Stimulator
    Bykov, V. V.
    Birulina, Yu G.
    Nosarev, A., V
    Vengerovskii, A., I
    Udut, V. V.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 174 (01) : 33 - 36
  • [32] Pharmacokinetics of the Soluble Guanylate Cyclase Activator Cinaciguat (BAY 58-2667) in Subjects with Hepatic Impairment
    Frey, Reiner
    Mueck, Wolfgang
    Unger, Sigrun
    Schmidt, Anja
    Wensing, Georg
    CIRCULATION, 2010, 122 (02) : E219 - E219
  • [33] Influence of the Soluble Guanylate Cyclase Stimulator Riociguat on Myocardial Function and Proteome after Experimental Aortic Stenosis in Mice
    Benkner, Alexander
    Ruedebusch, Julia
    Klingel, Karin
    Hammer, Elke
    Witt, Eric
    Dhople, Vishnu Mukund
    Doerr, Marcus
    Felix, Stephan
    Grube, Karina
    FASEB JOURNAL, 2018, 32 (01):
  • [34] Hemodynamic Effects of a Soluble Guanylate Cyclase Stimulator, Riociguat, and an Activator, Cinaciguat, During NO-Modulation in Healthy Pigs
    Naesheim, Torvind
    How, Ole-Jakob
    Myrmel, Truls
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2021, 26 (01) : 75 - 87
  • [35] THE SOLUBLE GUANYLATE CYCLASE STIMULATOR RIOCIGUAT IS THE FIRST-LINE THERAPY FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENTS
    Valieva, Z. S.
    Gratsianskaya, S. E.
    Martynyuk, T., V
    KARDIOLOGIYA, 2020, 60 (08) : 115 - 123
  • [36] The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats
    Lang, Michaela
    Kojonazarov, Baktybek
    Tian, Xia
    Kalymbetov, Anuar
    Weissmann, Norbert
    Grimminger, Friedrich
    Kretschmer, Axel
    Stasch, Johannes-Peter
    Seeger, Werner
    Ghofrani, Hossein Ardeschir
    Schermuly, Ralph Theo
    PLOS ONE, 2012, 7 (08):
  • [37] Spectroscopic methodologies and molecular docking studies on the interaction of the soluble guanylate cyclase stimulator riociguat with human serum albumin
    Ma, Rui
    Li, Zhenyu
    Di, Xiaxia
    Guo, Dongxiao
    Ji, Jianbo
    Wang, Shuqi
    BIOSCIENCE TRENDS, 2018, 12 (04) : 369 - 374
  • [38] Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
    Mittendorf, Joachim
    Weigand, Stefan
    Alonso-Alija, Cristina
    Bischoff, Erwin
    Feurer, Achim
    Gerisch, Michael
    Kern, Armin
    Knorr, Andreas
    Lang, Dieter
    Muenter, Klaus
    Radtke, Martin
    Schirok, Hartmut
    Schlemmer, Karl-Heinz
    Stahl, Elke
    Straub, Alexander
    Wunder, Frank
    Stasch, Johannes-Peter
    CHEMMEDCHEM, 2009, 4 (05) : 853 - 865
  • [39] The Effect Of The Soluble Guanylate Cyclase Stimulator Riociguat On Hemodynamics In Patients With Pulmonary Hypertension Due To Chronic Obstructive Pulmonary Disease
    Ghofrani, H. -A.
    Staehler, G.
    Gruenig, E.
    Halank, M.
    Mitrovic, V.
    Unger, S.
    Mueck, W.
    Frey, R.
    Behr, J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [40] A Phase 2 Study of the Soluble Guanylate Cyclase Stimulator Riociguat in Patients with Chronic Thromboembolic Pulmonary Hypertension or Pulmonary Arterial Hypertension
    Ghofrani, Hossein-Ardeschir
    Hoeper, Marius M.
    Halank, Michael
    Meyer, F. Joachim
    Staehler, Gerd
    Behr, Juergen
    Ewert, Ralf
    Weimann, Gerrit
    Grimminger, Friedrich
    CIRCULATION, 2010, 122 (02) : E239 - E239
12345