Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

被引:0
|
作者
Reiner Frey
Corina Becker
Sigrun Unger
Anja Schmidt
Georg Wensing
Wolfgang Mueck
机构
[1] Clinical Pharmacology,
[2] Bayer Pharma AG,undefined
[3] Pharma Research Centre,undefined
[4] Global Biostatistics,undefined
[5] Bayer Pharma AG,undefined
[6] Pharma Research Centre,undefined
关键词
Pulmonary Hypertension; Liver Cirrhosis; Hepatic Impairment; Oral Tablet; Moderate Hepatic Impairment;
D O I
10.1186/2050-6511-14-S1-P21
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Pharmacokinetics Of The Soluble Guanylate Cyclase Stimulator Riociguat In Individuals With Hepatic Impairment
    Frey, R.
    Becker, C.
    Unger, S.
    Schmidt, A.
    Wensing, G.
    Mueck, W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [2] Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment
    Frey, Reiner
    Becker, Corina
    Unger, Sigrun
    Schmidt, Anja
    Wensing, Georg
    Mueck, Wolfgang
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [3] Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment
    Reiner Frey
    Corina Becker
    Sigrun Unger
    Anja Schmidt
    Georg Wensing
    Wolfgang Mueck
    BMC Pharmacology and Toxicology, 14 (Suppl 1)
  • [4] Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat
    Reiner Frey
    John Lettieri
    Andrea Nadel
    Corina Becker
    Wolfgang Mück
    BMC Pharmacology and Toxicology, 14 (Suppl 1)
  • [5] Riociguat: Stimulator of Soluble Guanylate-cyclase
    Leuchte, H. H.
    Behr, J.
    Ewert, R.
    Ghofrani, H. A.
    Gruenig, E.
    Halank, M.
    Held, M.
    Klose, H.
    Rosenkranz, S.
    Schermuly, R. T.
    Wilkens, H.
    Hoeper, M. M.
    PNEUMOLOGIE, 2015, 69 (03): : 135 - 143
  • [6] Pharmacokinetics of the Soluble Guanylate Cyclase Activator Cinaciguat in Individuals With Hepatic Impairment
    Frey, Reiner
    Scheerans, Christian
    Blunck, Martin
    Mueck, Wolfgang
    Gnoth, Mark Jean
    Unger, Sigrun
    Schmidt, Anja
    Wensing, Georg
    JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 52 (11): : 1714 - 1724
  • [7] Assessment of the effects of hepatic impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)
    Frey, Reiner
    Becker, Corina
    Unger, Sigrun
    Schmidt, Anja
    Wensing, Georg
    Mueck, Wolfgang
    PULMONARY CIRCULATION, 2016, 6 : S5 - S14
  • [8] Riociguat: a soluble guanylate cyclase stimulator for the treatment of pulmonary hypertension
    Lian, Tian-Yu
    Jiang, Xin
    Jing, Zhi-Cheng
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2017, 11 : 1195 - 1207
  • [9] RIOCIGUAT Soluble Guanylate Cyclase Stimulator Treatment of Pulmonary Hypertension
    Mulligan, C.
    DRUGS OF THE FUTURE, 2009, 34 (06) : 468 - 475
  • [10] Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)
    Frey, Reiner
    Saleh, Soundos
    Becker, Corina
    Mueck, Wolfgang
    PULMONARY CIRCULATION, 2016, 6 : S58 - S65