Pathology of lupus nephritis [Pathologie der lupus-nephritis]

被引：0
|
作者：
Gröne E.F. [1 ]
Gröne H.J. [1 ,2 ]
机构：
[1] Abteilung Zelluläre and Molekulare Pathologie, Deutsches Krebsforschungszentrum, Heidelberg
[2] Abteilung Zelluläre and Molekulare Pathologie, Deutsches Krebsforschungszentrum, 69120 Heidelberg
来源：
Der Nephrologe | 2008年 / 3卷 / 3期
关键词：
Antibodies against nucleosomes; Antiphospholipid-antibodies; Apoptosis; Systemic lupus erythematosus;
D O I：
10.1007/s11560-008-0176-5
中图分类号：
学科分类号：
摘要：
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by synthesis of antinuclear antibodies. Nucleosomes, composed of histones and DNA, are the primary antigenic structure, which leads to complement-activating antigen-antibody complexes deposited at the glomerular basement membrane. The diagnostic work-up of skin and kidney biopsies-by light microscopy, immunohistology and electron microscopy-contributes significantly to the diagnosis, assessment of prognosis and therapeutic decisions. Semiquantitative scores of activity and chronicity improve the value of a histopathologic renal biopsy report. © 2008 Springer-Verlag.
引用
收藏
页码：195 / 202
页数：7
相关论文
共 50 条
  • [21] Lupus nephritis
    Hans-Joachim Anders
    Ramesh Saxena
    Ming-hui Zhao
    Ioannis Parodis
    Jane E. Salmon
    Chandra Mohan
    Nature Reviews Disease Primers, 6
  • [22] Lupus nephritis
    Anders, Hans-Joachim
    Saxena, Ramesh
    Zhao, Ming-hui
    Parodis, Ioannis
    Salmon, Jane E.
    Mohan, Chandra
    NATURE REVIEWS DISEASE PRIMERS, 2020, 6 (01)
  • [23] Lupus Nephritis
    Singh, Sandeep
    Saxena, Ramesh
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2009, 337 (06): : 451 - 460
  • [24] Lupus nephritis
    Mucke, Johanna
    Schneider, Matthias
    ZEITSCHRIFT FUR RHEUMATOLOGIE, 2023, 82 (01): : 40 - 52
  • [25] LUPUS NEPHRITIS
    RAITT, J
    HOLMAN, HR
    ARTHRITIS AND RHEUMATISM, 1962, 5 (05): : 517 - +
  • [26] Lupus nephritis
    Houssiau, F. A.
    REVUE DE MEDECINE INTERNE, 2007, 28 : S304 - S305
  • [27] Proteinuria in membranous lupus nephritis: the pathology is in the podocyte
    Desai, N.
    Cimbaluk, D.
    Lewis, E. J.
    Whittier, W. L.
    LUPUS, 2013, 22 (05) : 461 - 468
  • [28] Lupus nephritis
    Agrawal, N
    Chiang, LK
    Rifkin, IR
    SEMINARS IN NEPHROLOGY, 2006, 26 (02) : 95 - 104
  • [29] Lupus nephritis
    Melderis, S.
    Wiech, T.
    Iking-Konert, C.
    Steinmetz, O. M.
    ZEITSCHRIFT FUR RHEUMATOLOGIE, 2018, 77 (07): : 593 - 608
  • [30] LUPUS NEPHRITIS
    PENASANCHEZDERIVERA, JM
    VAZQUEZRODRIGUEZ, JJ
    CALVOMANUEL, F
    REDONDOSANCHEZ, C
    BARBADOHERNANDEZ, FJ
    GILAGUADO, A
    ORTIZVAZQUEZ, J
    MEDICINA CLINICA, 1980, 75 (06): : 229 - 234
12345