Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

被引:0
|
作者
Yizheng Zhang
Chuchu Zhang
Jiehan Li
Meimei Jiang
Shuning Guo
Ge Yang
Lingling Zhang
Feng Wang
Shiqi Yi
Jiangang Wang
Yang Fu
Yingjie Zhang
机构
[1] The Third Xiangya Hospital,Department of Health Management
[2] Central South University,Department of Gastrointestinal Surgery
[3] The First Affiliated Hospital of Zhengzhou University,School of Biomedical Sciences
[4] Hunan University,Department of Ophthalmology
[5] The First Affiliated Hospital of Zhengzhou University,Department of Laboratory Medicine
[6] The Third Xiangya Hospital,Department of Gastroenterology
[7] Central South University,Center for Reproductive Medicine
[8] The Tenth People’s Hospital of Shanghai,College of Biology
[9] Tongji University,Department of Pathology and Neuropathology
[10] The First Affiliated Hospital of Zhengzhou University,undefined
[11] Hunan University,undefined
[12] University Hospital Tuebingen,undefined
关键词
AKT; p53; Parthanatos; Cell death; SIRT6; Colorectal cancer;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth
    Zhang, Yizheng
    Zhang, Chuchu
    Li, Jiehan
    Jiang, Meimei
    Guo, Shuning
    Yang, Ge
    Zhang, Lingling
    Wang, Feng
    Yi, Shiqi
    Wang, Jiangang
    Fu, Yang
    Zhang, Yingjie
    CELL COMMUNICATION AND SIGNALING, 2022, 20 (01)
  • [2] SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
    Xu, Zhu
    Zhang, Lei
    Zhang, Wenjun
    Meng, Du
    Zhang, Hongxia
    Jiang, Ying
    Xu, Xiaojun
    Van Meter, Michael
    Seluanov, Andrei
    Gorbunova, Vera
    Mao, Zhiyong
    CELL CYCLE, 2015, 14 (02) : 269 - 276
  • [3] Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion
    Zhang, Ping
    Tu, Bo
    Wang, Hua
    Cao, Ziyang
    Tang, Ming
    Zhang, Chaohua
    Gu, Bo
    Li, Zhiming
    Wang, Lina
    Yang, Yang
    Zhao, Ying
    Wang, Haiying
    Luo, Jianyuan
    Deng, Chu-Xia
    Gao, Bin
    Roeder, Robert G.
    Zhu, Wei-Guo
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (29) : 10684 - 10689
  • [4] p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis
    Li, Meiting
    Hou, Tianyun
    Gao, Tian
    Lu, Xiaopeng
    Yang, Qiaoyan
    Zhu, Qian
    Li, Zhiming
    Liu, Chaohua
    Mu, Guanqun
    Liu, Ge
    Bao, Yantao
    Wen, He
    Wang, Lina
    Wang, Haiying
    Zhao, Ying
    Gu, Wei
    Yang, Yang
    Zhu, Wei-Guo
    CELL DEATH & DISEASE, 2018, 9
  • [5] p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis
    Meiting Li
    Tianyun Hou
    Tian Gao
    Xiaopeng Lu
    Qiaoyan Yang
    Qian Zhu
    Zhiming Li
    Chaohua Liu
    Guanqun Mu
    Ge Liu
    Yantao Bao
    He Wen
    Lina Wang
    Haiying Wang
    Ying Zhao
    Wei Gu
    Yang Yang
    Wei-Guo Zhu
    Cell Death & Disease, 9
  • [6] Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6
    Wood, Marci
    Rymarchyk, Stacia
    Zheng, Song
    Cen, Yana
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 638 : 8 - 17
  • [7] p53 induces transcriptional and translational programs to suppress cell proliferation and growth
    Fabricio Loayza-Puch
    Jarno Drost
    Koos Rooijers
    Rui Lopes
    Ran Elkon
    Reuven Agami
    Genome Biology, 14
  • [8] p53 induces transcriptional and translational programs to suppress cell proliferation and growth
    Loayza-Puch, Fabricio
    Drost, Jarno
    Rooijers, Koos
    Lopes, Rui
    Elkon, Ran
    Agami, Reuven
    GENOME BIOLOGY, 2013, 14 (04):
  • [9] Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT
    Yu, Angel C. Y.
    Chern, Yi-Jye
    Zhang, Peter
    Pasiliao, Clarissa C.
    Rahman, Mahbuba
    Chang, George
    Ren, Jianhua
    Tai, Isabella T.
    CANCER BIOLOGY & THERAPY, 2021, 22 (02) : 112 - 123
  • [10] Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells
    Koetter, Annika
    Cornils, Kerstin
    Borgmann, Kerstin
    Dahm-Daphi, Jochen
    Petersen, Cordula
    Dikomey, Ekkehard
    Mansour, Wael Y.
    MOLECULAR ONCOLOGY, 2014, 8 (08) : 1616 - 1625