Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants

被引:0
|
作者
Diana Jansen
Heder de Vries
Leo M. A. Heunks
机构
[1] Radboud University Medical Center,Department of Anesthesiology
[2] VU University Medical Center Amsterdam,Department of Intensive Care Medicine
来源
Critical Care | / 22卷
关键词
Neuromuscular blockers; Acute respiratory distress syndrome; Direct anti-inflammatory effect; Acetylcholine; Acetylcholine receptors; Lung injury markers; Respiratory muscles; Low tidal volume ventilation; Partial neuromuscular blockade;
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摘要
Acetylcholine receptor antagonists have been shown to improve outcome in patients with severe acute respiratory distress syndrome. However, it is incompletely understood how these agents improve outcome. In the current editorial, we discuss the mechanisms of action of acetylcholine receptor antagonists beyond neuromuscular blockade.
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