Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy

被引：0

作者：

N Hayashi

M Urashima

I Ikemoto

H Kuruma

Y Arai

S Kuwao

S Baba

S Egawa

机构：

[1] Jikei University School of Medicine,Department of Urology

[2] Jikei University School of Medicine,Division of Clinical Research and Development

[3] Tohoku University Graduate School of Medicine,Department of Urology

[4] Higashi-Yamato Hospital,Department of Pathology

[5] Kitasato University School of Medicine,Department of Urology

来源：

Prostate Cancer and Prostatic Diseases | 2007年 / 10卷

关键词：

prognosis; PSA; tumor volume; PSA tumor density;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The aim of this study was to investigate the potential prognostic value of preoperative serum prostate-specific antigen levels adjusted for total tumor volume (PSA-TTV density) for outcome following radical prostatectomy for prostate cancer by retrospective review in 268 patients. Lower PSA-TTV density was not only associated with a significantly higher risk for biological failure (bF), systemic failure and cancer death but also an independent predictor for bF (hazard ratio, 6.3). Therefore, these data suggest that there are subsets of prostate cancer with lower PSA secretion levels, and this phenotype is associated with a higher risk of failure after surgery.

引用

页码：60 / 65

页数：5

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