Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

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作者：

Anne Marie Rosendahl Madsen

Frederik Schaltz-Buchholzer

Thomas Benfield

Morten Bjerregaard-Andersen

Lars Skov Dalgaard

Christine Dam

Sisse Bolm Ditlev

Gulia Faizi

Isik Somuncu Johansen

Poul-Erik Kofoed

Gitte Schultz Kristensen

Ellen Christine Leth Loekkegaard

Christian Backer Mogensen

Libin Mohamed

Anne Ostenfeld

Emilie Sundhaugen Oedegaard

Marcus Kjaer Soerensen

Christian Wejse

Aksel Karl Georg Jensen

Sebastian Nielsen

Tyra Grove Krause

Mihai G. Netea

Peter Aaby

Christine Stabell Benn

机构：

[1] University of Southern Denmark/Odense University Hospital,Bandim Health Project, OPEN, Department of Clinical Research

[2] Copenhagen University Hospital,Center of Research & Disruption of Infectious Diseases (CREDID), Department of Infectious Diseases

[3] Amager and Hvidovre Hospital,Department of Medicine

[4] Sydvestjysk Hospital,Department of Medicine

[5] Herning Hospital,Department of Respiratory Medicine

[6] Bispebjerg and Frederiksberg Hospital,Department of Infectious Diseases

[7] The Copenhagen Center for Translational Research (CCTR),Department of Pediatrics

[8] Bispebjerg Hospital,Department of Medicine

[9] Odense University Hospital,Department of Gynaecology and Obstetrics

[10] Lillebaelt Hospital,Department of Infectious Diseases

[11] Soenderjylland Hospital,Section of Biostatistics, Department of Public Health

[12] Nordsjaellands Hospital,Department of Internal Medicine

[13] Aarhus University Hospital,Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES)

[14] University of Copenhagen,undefined

[15] Statens Serum Institut,undefined

[16] Radboud University Medical Centre,undefined

[17] University of Bonn,undefined

来源：

Trials | / 21卷

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摘要：

Objectives: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is associated with non- specific protective effects against other infections, and significant reductions in all-cause morbidity and mortality have been reported. We aim to test whether BCG vaccination may reduce susceptibility to and/or the severity of COVID-19 and other infectious diseases in health care workers (HCW) and thus prevent work absenteeism.

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