Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

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作者：

Anne Marie Rosendahl Madsen

Frederik Schaltz-Buchholzer

Thomas Benfield

Morten Bjerregaard-Andersen

Lars Skov Dalgaard

Christine Dam

Sisse Bolm Ditlev

Gulia Faizi

Isik Somuncu Johansen

Poul-Erik Kofoed

Gitte Schultz Kristensen

Ellen Christine Leth Loekkegaard

Christian Backer Mogensen

Libin Mohamed

Anne Ostenfeld

Emilie Sundhaugen Oedegaard

Marcus Kjaer Soerensen

Christian Wejse

Aksel Karl Georg Jensen

Sebastian Nielsen

Tyra Grove Krause

Mihai G. Netea

Peter Aaby

Christine Stabell Benn

机构：

[1] University of Southern Denmark/Odense University Hospital,Bandim Health Project, OPEN, Department of Clinical Research

[2] Copenhagen University Hospital,Center of Research & Disruption of Infectious Diseases (CREDID), Department of Infectious Diseases

[3] Amager and Hvidovre Hospital,Department of Medicine

[4] Sydvestjysk Hospital,Department of Medicine

[5] Herning Hospital,Department of Respiratory Medicine

[6] Bispebjerg and Frederiksberg Hospital,Department of Infectious Diseases

[7] The Copenhagen Center for Translational Research (CCTR),Department of Pediatrics

[8] Bispebjerg Hospital,Department of Medicine

[9] Odense University Hospital,Department of Gynaecology and Obstetrics

[10] Lillebaelt Hospital,Department of Infectious Diseases

[11] Soenderjylland Hospital,Section of Biostatistics, Department of Public Health

[12] Nordsjaellands Hospital,Department of Internal Medicine

[13] Aarhus University Hospital,Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES)

[14] University of Copenhagen,undefined

[15] Statens Serum Institut,undefined

[16] Radboud University Medical Centre,undefined

[17] University of Bonn,undefined

来源：

Trials | / 21卷

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摘要：

Objectives: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is associated with non- specific protective effects against other infections, and significant reductions in all-cause morbidity and mortality have been reported. We aim to test whether BCG vaccination may reduce susceptibility to and/or the severity of COVID-19 and other infectious diseases in health care workers (HCW) and thus prevent work absenteeism.

引用

共 50 条

[1] Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark
Madsen, Anne Marie Rosendahl
Schaltz-Buchholzer, Frederik
Benfield, Thomas
Bjerregaard-Andersen, Morten
Dalgaard, Lars Skov
Dam, Christine
Ditlev, Sisse Bolm
Faizi, Gulia
Johansen, Isik Somuncu
Kofoed, Poul-Erik
Kristensen, Gitte Schultz
Loekkegaard, Ellen Christine Leth
Mogensen, Christian Backer
Mohamed, Libin
Ostenfeld, Anne
Oedegaard, Emilie Sundhaugen
Soerensen, Marcus Kjaer
Wejse, Christian
Jensen, Aksel Karl Georg
Nielsen, Sebastian
Krause, Tyra Grove
Netea, Mihai G.
Aaby, Peter
Benn, Christine Stabell
[J]. TRIALS, 2020, 21 (01)
[2] Using BCG Vaccine to Enhance Nonspecific Protection of Health Care Workers During the COVID-19 Pandemic: A Randomized Controlled Trial
Madsen, Anne Marie Rosendahl
Schaltz-Buchholzer, Frederik
Nielsen, Sebastian
Benfield, Thomas
Bjerregaard-Andersen, Morten
Dalgaard, Lars Skov
Dam, Christine
Ditlev, Sisse Bolm
Faizi, Gulia
Azizi, Mihnaz
Hameed, Zainab Nadhim
Johansen, Isik Somuncu
Kofoed, Poul-Erik
Krause, Tyra Grove
Kristensen, Gitte Schultz
Loekkegaard, Ellen Christine Leth
Mogensen, Christian Backer
Mohamed, Libin
Oedegaard, Emilie Sundhaugen
Ostenfeld, Anne
Soerensen, Marcus Kjaer
Wejse, Christian
Netea, Mihai G.
Aaby, Peter
Benn, Christine Stabell
[J]. JOURNAL OF INFECTIOUS DISEASES, 2024, 229 (02): : 384 - 393
[3] BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial
Junqueira-Kipnis, Ana Paula
Borges dos Anjos, Laura Raniere
de Souza Barbosa, Lilia Cristina
da Costa, Adeliane Castro
Malheiros Borges, Kellen Christina
Oliveira Cardoso, Amanda da Rocha
Ribeiro, Kaio Mota
Aparecida Rosa, Sarah Brena
Souza, Carine de Castro
das Neves, Rogerio Coutinho
Saraiva, Guylherme
da Silva, Sueli Meira
da Silveira, Erika Aparecida
Rabahi, Marcelo Fouad
Conte, Marcus Barreto
Kipnis, Andre
[J]. TRIALS, 2020, 21 (01)
[4] BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial
Ana Paula Junqueira-Kipnis
Laura Raniere Borges dos Anjos
Lília Cristina de Souza Barbosa
Adeliane Castro da Costa
Kellen Christina Malheiros Borges
Amanda da Rocha Oliveira Cardoso
Kaio Mota Ribeiro
Sarah Brena Aparecida Rosa
Carine de Castro Souza
Rogério Coutinho das Neves
Guylherme Saraiva
Sueli Meira da Silva
Erika Aparecida Silveira
Marcelo Fouad Rabahi
Marcus Barreto Conte
André Kipnis
[J]. Trials, 21
[5] Correction to: BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial
Ana Paula Junqueira-Kipnis
Laura Raniere Borges dos Anjos
Lília Cristina de Souza Barbosa
Adeliane Castro da Costa
Kellen Christina Malheiros Borges
Amanda da Rocha Oliveira Cardoso
Kaio Mota Ribeiro
Sarah Brena Aparecida Rosa
Carine de Castro Souza
Rogério Coutinho das Neves
Guylherme Saraiva
Sueli Meira da Silva
Erika Aparecida Silveira
Marcelo Fouad Rabahi
Marcus Barreto Conte
André Kipnis
[J]. Trials, 21
[6] Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemic (Sleep COVID-19): structured summary of a study protocol for a randomised controlled trial
Elder, Greg J.
Alfonso-Miller, Pamela
Atkinson, William C. M.
Santhi, Nayantara
Ellis, Jason G.
[J]. TRIALS, 2020, 21 (01)
[7] Testing an early online intervention for the treatment of disturbed sleep during the COVID-19 pandemic (Sleep COVID-19): structured summary of a study protocol for a randomised controlled trial
Greg J. Elder
Pamela Alfonso-Miller
William C. M. Atkinson
Nayantara Santhi
Jason G. Ellis
[J]. Trials, 21
[8] Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG - RAPID Trial): A structured summary of a study protocol for a randomised controlled trial
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Tang, Grace H.
Negri, Elnara
Rahhal, Hassan
Kreuziger, Lisa Baumann
Pompilio, Carlos E.
James, Paula
Fralick, Michael
AlHamzah, Musaad
Alomran, Faris
Tseng, Eric
Lim, Gloria
Lillicrap, David
Carrier, Marc
Ainle, Fionnuala Ni
Beckett, Andrew
da Costa, Bruno R.
Thorpe, Kevin
Middeldorp, Saskia
Lee, Agnes
Cushman, Mary
Juni, Peter
[J]. TRIALS, 2021, 22 (01)
[9] Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG – RAPID Trial): A structured summary of a study protocol for a randomised controlled trial
Michelle Sholzberg
Grace H. Tang
Elnara Negri
Hassan Rahhal
Lisa Baumann Kreuziger
Carlos E. Pompilio
Paula James
Michael Fralick
Musaad AlHamzah
Faris Alomran
Eric Tseng
Gloria Lim
David Lillicrap
Marc Carrier
Fionnuala Ní Áinle
Andrew Beckett
Bruno R. da Costa
Kevin Thorpe
Saskia Middeldorp
Agnes Lee
Mary Cushman
Peter Jüni
[J]. Trials, 22
[10] BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trial (vol 21, 881, 2020)
Junqueira-Kipnis, Ana Paula
dos Anjos, Laura Raniere Borges
de Souza Barbosa, Lilia Cristina
da Costa, Adeliane Castro
Borges, Kellen Christina Malheiros
da Rocha Oliveira Cardoso, Amanda
Ribeiro, Kaio Mota
Rosa, Sarah Brena Aparecida
de Castro Souza, Carine
das Neves, Rogerio Coutinho
Saraiva, Guylherme
da Silva, Sueli Meira
Silveira, Erika Aparecida
Rabahi, Marcelo Fouad
Conte, Marcus Barreto
Kipnis, Andre
[J]. TRIALS, 2020, 21 (01)

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