IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis

被引：0

作者：

Liling Zhang

Courtney Nosak

Pietro Sollazzo

Tanya Odisho

Allen Volchuk

机构：

[1] University Health Network,Division of Advanced Diagnostics

[2] University of Toronto,Metabolism, Toronto General Research Institute

[3] University of Toronto,Department of Physiology

来源：

BMC Cell Biology | / 15卷

关键词：

Endoplasmic reticulum stress; ER-associated degradation (ERAD); Proinsulin biosynthesis; Pancreatic beta-cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 48 条

[21] Unfolded Protein Response in Cancer: IRE1a Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability
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ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (01): : 68 - 72
[22] Dual Regulation of Cadmium-Induced Apoptosis by mTORC1 through Selective Induction of IRE1 Branches in Unfolded Protein Response
Kato, Hironori
Katoh, Ryohei
Kitamura, Masanori
PLOS ONE, 2013, 8 (05):
[23] Block of Counter-Regulation By Inhibition of Protein Synthesis Sensitizes Cancer Cells to IRE1a-Mediated Apoptosis Following Unfolded Protein Response
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Meier, Christina
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BLOOD, 2022, 140 : 3122 - 3122
[24] Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (14) : 5713 - 5718
[25] Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer
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You, Lixin
Zhang, Li
Guo, Xichen
Guo, Ensong
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Li, Xi
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Li, Wenting
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Dou, Yingyu
Liu, Jingbo
Wang, Wei
Qin, Tianyu
Cui, Yaoyuan
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Li, Fuxia
Jin, Yang
Zeng, Qingping
Wang, Beibei
Mills, Gordon B.
Chen, Gang
Sheng, Xia
Sun, Chaoyang
ADVANCED SCIENCE, 2022, 9 (21)
[26] Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
Soustek, Meghan S.
Balsa, Eduardo
Barrow, Joeva J.
Jedrychowski, Mark
Vogel, Rutger
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Gygi, Steve P.
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CELL DEATH & DISEASE, 2018, 9
[27] Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
Meghan S. Soustek
Eduardo Balsa
Joeva J. Barrow
Mark Jedrychowski
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Pere Gygi
Cell Death & Disease, 9
[28] Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response
Yuki Taguchi
Yuta Horiuchi
Fumi Kano
Masayuki Murata
Cell Death & Disease, 2017, 8 : e2718 - e2718
[29] Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response
Taguchi, Yuki
Horiuchi, Yuta
Kano, Fumi
Murata, Masayuki
CELL DEATH & DISEASE, 2017, 8 : e2718 - e2718
[30] IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties
Jiangwei Xiao
Jingwen Huang
Xiaoting Jian
Han Wang
Haiqiang Lan
Zhaohong Liao
Ruicai Gu
Jijie Hu
Hua Liao
Cellular & Molecular Biology Letters, 28

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