IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis

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作者：
Liling Zhang
Courtney Nosak
Pietro Sollazzo
Tanya Odisho
Allen Volchuk
机构：
[1] University Health Network,Division of Advanced Diagnostics
[2] University of Toronto,Metabolism, Toronto General Research Institute
[3] University of Toronto,Department of Physiology
来源：
BMC Cell Biology | / 15卷
关键词：
Endoplasmic reticulum stress; ER-associated degradation (ERAD); Proinsulin biosynthesis; Pancreatic beta-cells;
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