Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.
机构:
Univ Penn, Blood & Marrow Transplantat, Med Ctr, Philadelphia, PA 19104 USAUniv Penn, Blood & Marrow Transplantat, Med Ctr, Philadelphia, PA 19104 USA