The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

被引：0
|
作者：
Xu Lu
Matthew D Simon
Jayanth V Chodaparambil
Jeffrey C Hansen
Kevan M Shokat
Karolin Luger
机构：
[1] Colorado State University,Department of Biochemistry and Molecular Biology
[2] 1870 Campus Delivery,undefined
[3] Cellular and Molecular Pharmacology,undefined
[4] University of California,undefined
[5] San Francisco,undefined
[6] Howard Hughes Medical Institute,undefined
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
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摘要：
Histone methylation has important consequences for chromatin activity. Now, histones with methyllysine analogs are used to reconstitute nucleosomes: the crystal structures show no global changes in nucleosomes with H3K79me2 and H4K20me3, but the latter modification enhances compaction of nucleosomal arrays.
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页码：1122 / 1124
页数：2
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