The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

被引：0
|
作者：
Xu Lu
Matthew D Simon
Jayanth V Chodaparambil
Jeffrey C Hansen
Kevan M Shokat
Karolin Luger
机构：
[1] Colorado State University,Department of Biochemistry and Molecular Biology
[2] 1870 Campus Delivery,undefined
[3] Cellular and Molecular Pharmacology,undefined
[4] University of California,undefined
[5] San Francisco,undefined
[6] Howard Hughes Medical Institute,undefined
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Histone methylation has important consequences for chromatin activity. Now, histones with methyllysine analogs are used to reconstitute nucleosomes: the crystal structures show no global changes in nucleosomes with H3K79me2 and H4K20me3, but the latter modification enhances compaction of nucleosomal arrays.
引用
收藏
页码：1122 / 1124
页数：2
相关论文
共 50 条
  • [1] The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure
    Lu, Xu
    Simon, Matthew D.
    Chodaparambil, Jayanth V.
    Hansen, Jeffrey C.
    Shokat, Kevan M.
    Luger, Karolin
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (10) : 1122 - 1124
  • [2] Menin, the COMPASS to locate H3K79 dimethylation
    Zhou, Qinchao
    Xiong, Jun
    Zhu, Bing
    SCIENCE BULLETIN, 2023, 68 (06) : 565 - 567
  • [3] Histone H4K20 Trimethylation Is Differentially Regulated In Heart Disease
    Hickenlooper, Samuel
    Davis, Kathryn
    Valdez, Steven
    Bia, Ryan
    Szulik, Marta
    Franklin, Sarah
    CIRCULATION RESEARCH, 2021, 129
  • [4] H4K20 methylation regulates quiescence and chromatin compaction
    Evertts, Adam G.
    Manning, Amity L.
    Wang, Xin
    Dyson, Nicholas J.
    Garcia, Benjamin A.
    Coller, Hilary A.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (19) : 3025 - 3037
  • [5] Histone H4K20 Trimethylation Is Decreased in Murine Models of Heart Disease
    Hickenlooper, Samuel M.
    Davis, Kathryn
    Szulik, Marta W.
    Sheikh, Hanin
    Miller, Mickey
    Valdez, Steven
    Bia, Ryan
    Franklin, Sarah
    ACS OMEGA, 2022, 7 (35): : 30710 - 30719
  • [6] Global increase in H3K79 dimethylation in murine and human MLL-AF4 lymphoblastic leukemias
    Krivtsov, Andrei V.
    Feng, Zhaohui
    Lemieux, Madeleine
    Faber, Joerg
    Xia, Xiaobo
    Kung, Andrew L.
    Armstrong, Scott A.
    BLOOD, 2007, 110 (11) : 108A - 108A
  • [7] Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1
    Nakanishi, Shima
    Lee, Jung Shin
    Gardner, Kathryn E.
    Gardner, Jennifer M.
    Takahashi, Yoh-hei
    Chandrasekharan, Mahesh B.
    Sun, Zu-Wen
    Osley, Mary Ann
    Strahl, Brian D.
    Jaspersen, Sue L.
    Shilatifard, Ali
    JOURNAL OF CELL BIOLOGY, 2009, 186 (03): : 371 - 377
  • [8] Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing
    Bierhoff, Holger
    Dammert, Marcel Andre
    Brocks, David
    Dambacher, Silvia
    Schotta, Gunnar
    Grummt, Ingrid
    MOLECULAR CELL, 2014, 54 (04) : 675 - 682
  • [9] Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer
    Benard, Anne
    Goossens-Beumer, Ines J.
    van Hoesel, Anneke Q.
    de Graaf, Wouter
    Horati, Hamed
    Putter, Hein
    Zeestraten, Eliane C. M.
    van de Velde, Cornelis J. H.
    Kuppen, Peter J. K.
    BMC CANCER, 2014, 14
  • [10] Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20
    Stender, Joshua D.
    Pascual, Gabriel
    Liu, Wen
    Kaikkonen, Minna U.
    Do, Kevin
    Spann, Nathanael J.
    Boutros, Michael
    Perrimon, Norbert
    Rosenfeld, Michael G.
    Glass, Christopher K.
    MOLECULAR CELL, 2012, 48 (01) : 28 - 38
12345