Whole-Cell Mechanosensitive Currents in Rat Ventricular Myocytes Activated by Direct Stimulation

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作者
G.C.L. Bett
F. Sachs
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[1] Department of Physiology and Biophysics,
[2] 124 Sherman Hall,undefined
[3] SUNY,undefined
[4] Buffalo,undefined
[5] NY 14214,undefined
[6] USA,undefined
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Key words: Ion channel — Patch clamp — Mechanical — Cytoskeleton;
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Mechanosensitive channels may have a significant role in the development of cardiac arrhythmia following infarction, but the data on mechanical responses at the cellular level are limited. Mechanosensitivity is a ubiquitous property of cells, and although the structure of bacteriological mechanosensitive ion channels is becoming known by cloning, the structure and force transduction pathway in eukaryotes remains elusive.
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页码:255 / 263
页数:8
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