Double overexpression of miR-19a and miR-20a in induced pluripotent stem cell-derived mesenchymal stem cells effectively preserves the left ventricular function in dilated cardiomyopathic rat

被引:0
|
作者
Jiunn-Jye Sheu
Han-Tan Chai
Pei-Hsun Sung
John Y. Chiang
Tien-Hung Huang
Pei-Lin Shao
Shun-Cheng Wu
Hon-Kan Yip
机构
[1] Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine,Division of Thoracic and Cardiovascular Surgery, Department of Surgery
[2] Kaohsiung Chang Gung Memorial Hospital and Chang Gung University,Division of Cardiology, Department of Internal Medicine
[3] College of Medicine,Center for Shockwave Medicine and Tissue Engineering
[4] Kaohsiung Chang Gung Memorial Hospital,Institute for Translational Research in Biomedicine
[5] Kaohsiung Chang Gung Memorial Hospital,Department of Computer Science and Engineering
[6] National Sun Yat-Sen University,Department of Healthcare Administration and Medical Informatics
[7] Kaohsiung Medical University,Department of Nursing
[8] Asia University,Regenerative Medicine and Cell Therapy Research Center
[9] Kaohsiung Medical University,Orthopaedic Research Center
[10] Kaohsiung Medical University,Post
[11] Asia University,Baccalaureate Program in Nursing
[12] China Medical University,Department of Medical Research, China Medical University Hospital
[13] Xiamen Chang Gung Hospital,Division of Cardiology, Department of Internal Medicine
关键词
Dilated cardiomyopathy; Double overexpression of microRNAs; Oxidative stress; Inflammation; Mitochondrial damage;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 45 条
  • [1] Double overexpression of miR-19a and miR-20a in induced pluripotent stem cell-derived mesenchymal stem cells effectively preserves the left ventricular function in dilated cardiomyopathic rat
    Sheu, Jiunn-Jye
    Chai, Han-Tan
    Sung, Pei-Hsun
    Chiang, John Y.
    Huang, Tien-Hung
    Shao, Pei-Lin
    Wu, Shun-Cheng
    Yip, Hon-Kan
    STEM CELL RESEARCH & THERAPY, 2021, 12 (01)
  • [2] Overexpression of miR-19a and miR-20a in iPS-MSCs preserves renal function of chronic kidney disease with acute ischaemia-reperfusion injury in rat
    Lee, Mel S.
    Yip, Hon-Kan
    Yang, Chih-Chao
    Chiang, John Y.
    Huang, Tien-Hung
    Li, Yi-Chen
    Chen, Kuan-Hung
    Sung, Pei-Hsun
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (16) : 7675 - 7689
  • [3] Overexpression of myocardin induces partial transdifferentiation of human-induced pluripotent stem cell-derived mesenchymal stem cells into cardiomyocytes
    Zhang, Jiao
    Ho, Jenny Chung-Yee
    Chan, Yau-Chi
    Lian, Qizhou
    Siu, Chung-Wah
    Tse, Hung-Fat
    PHYSIOLOGICAL REPORTS, 2014, 2 (02):
  • [4] An in Vitro and in Vivo Study of the Effect of Dexamethasone on Immunoinhibitory Function of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
    Wang, Dan
    Sun, Yue-Qi
    Gao, Wen-Xiang
    Fan, Xing-Liang
    Shi, Jian-Bo
    Fu, Qing-Ling
    CELL TRANSPLANTATION, 2018, 27 (09) : 1340 - 1351
  • [5] The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells
    Chen, Juan
    Chen, Xuan
    Yao, Jianfeng
    Li, Ming
    Yang, Xiaoyu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 516 (01) : 307 - 312
  • [6] miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy
    Wei, Shanshan
    Zhang, Zhiwen
    Yan, Lu
    Mo, Yinjuan
    Qiu, Xianwen
    Mi, Xiangbin
    Lai, Kuan
    STEM CELLS INTERNATIONAL, 2021, 2021
  • [7] Human induced pluripotent stem cell-derived mesenchymal stem cell therapy effectively reduced brain infarct volume and preserved neurological function in rat after acute intracranial hemorrhage
    Li, Y. C.
    Lee, F. Y.
    Chua, S.
    Yip, H. K.
    EUROPEAN HEART JOURNAL, 2019, 40 : 3614 - 3614
  • [8] Human induced pluripotent stem cell-derived mesenchymal stem cell therapy effectively reduced brain infarct volume and preserved neurological function in rat after acute intracranial hemorrhage
    Chen, Kuan-Hung
    Lin, Kun-Chen
    Wallace, Christopher Glenn
    Li, Yi-Chen
    Shao, Pei-Lin
    Chiang, John Y.
    Sung, Pei-Hsun
    Yip, Hon-Kan
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2019, 11 (09): : 6232 - 6248
  • [9] Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model
    Mitsuzawa, Sadaki
    Ikeguchi, Ryosuke
    Aoyama, Tomoki
    Ando, Maki
    Takeuchi, Hisataka
    Yurie, Hirofumi
    Oda, Hiroki
    Noguchi, Takashi
    Ohta, Souichi
    Zhao, Chengzhu
    Ikeya, Makoto
    Matsuda, Shuichi
    MICROSURGERY, 2019, 39 (08) : 737 - 747
  • [10] MiR-126 enhances VEGF expression in induced pluripotent stem cell-derived retinal neural stem cells by targeting spred-1
    Ye, Lin
    Peng, Yun
    Mo, Jinsong
    Yao, Yuanyuan
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2018, 11 (02): : 1023 - 1030