HPLC determination of tetracycline antibiotics in milk with post-column derivatization and fluorescence detection

被引：0
|
作者：
I. D. Kargin
L. S. Sokolova
A. V. Pirogov
O. A. Shpigun
机构：
[1] Moscow State University,
来源：
Inorganic Materials | 2016年 / 52卷
关键词：
antibiotics; tetracyclines; microemulsions; HPLC;
D O I：
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中图分类号：
学科分类号：
摘要：
The conditions for sensitive and selective determination of tetracyclines in milk in the form of their complexes with Mg2+ via the HPLC method with post-column derivatization and fluorescence detection are found. It is shown that the fluorescence of tetracycline-Mg2+ complexes in microemulsions is 1.8 times more intense than that in aqueous acetonitrile medium. The detection limits of tetracycline, oxytetracycline, and doxycycline are 5, 8 and 25 ng mL–1, respectively.
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页码：1365 / 1369
页数：4
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