Genome partitioning of genetic variation for complex traits using common SNPs

被引：0

作者：

Jian Yang

Teri A Manolio

Louis R Pasquale

Eric Boerwinkle

Neil Caporaso

Julie M Cunningham

Mariza de Andrade

Bjarke Feenstra

Eleanor Feingold

M Geoffrey Hayes

William G Hill

Maria Teresa Landi

Alvaro Alonso

Guillaume Lettre

Peng Lin

Hua Ling

William Lowe

Rasika A Mathias

Mads Melbye

Elizabeth Pugh

Marilyn C Cornelis

Bruce S Weir

Michael E Goddard

Peter M Visscher

机构：

[1] Queensland Statistical Genetics Laboratory,Human Genetics Center and Division of Epidemiology

[2] Queensland Institute of Medical Research,Division of Cancer Epidemiology and Genetics

[3] Office of Population Genomics,Department of Laboratory Medicine and Pathology

[4] National Human Genome Research Institute (NHGRI),Division of Biomedical Statistics and Informatics

[5] Massachussetts Eye and Ear Infirmary,Department of Epidemiology Research

[6] Harvard Medical School,Department of Human Genetics

[7] University of Texas Health Science Center,Division of Endocrinology

[8] National Cancer Institute (NCI),Division of Cancer Epidemiology and Genetics

[9] Mayo Clinic College of Medicine,Division of Epidemiology and Community Health

[10] Mayo Clinic,Department of General Internal Medicine

[11] Statens Serum Institut,Department of Nutrition

[12] University of Pittsburgh,Department of Biostatistics

[13] Metabolism and Molecular Medicine,Department of Food and Agricultural Systems

[14] Feinberg School of Medicine,undefined

[15] Northwestern University,undefined

[16] Institute of Evolutionary Biology,undefined

[17] University of Edinburgh,undefined

[18] NCI,undefined

[19] University of Minnesota,undefined

[20] Montréal Heart Institute,undefined

[21] Université de Montréal,undefined

[22] Human and Statistical Genetics Program,undefined

[23] School of Medicine,undefined

[24] Washington University,undefined

[25] Center for Inherited Disease Research,undefined

[26] Johns Hopkins University School of Medicine,undefined

[27] Feinberg School of Medicine,undefined

[28] Northwestern University,undefined

[29] Johns Hopkins University School of Medicine,undefined

[30] School of Public Health,undefined

[31] Harvard University,undefined

[32] University of Washington,undefined

[33] University of Melbourne,undefined

[34] Biosciences Research Division,undefined

[35] Department of Primary Industries,undefined

来源：

Nature Genetics | 2011年 / 43卷

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学科分类号：

摘要：

Peter Visscher and colleagues report an analysis to partition the genetic variation for several complex traits onto chromosome segments and find that the variation explained is approximately proportional to the total length of genes included within a chromosome segment. They estimate that ~45%, ~17%, ~25% and ~21% of the phenotypic variation, respectively, for height, body mass index, von Willebrand factor and QT interval is tagged by common SNPs, and they partition this variation by chromosome and chromosome segments.

引用

页码：519 / 525

页数：6

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