Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts

被引：0

作者：

Stepanova, O. V. ^{[1
,5
]}

Fursa, G. A. ^{[1
]}

Karsuntseva, E. K. ^{[1
]}

Andretsova, S. S. ^{[1
,4
]}

Chadin, A. V. ^{[1
]}

Voronova, A. D. ^{[1
]}

Shishkina, V. S. ^{[1
]}

Semkina, A. S. ^{[1
,2
]}

Reshetov, I. V. ^{[3
]}

Chekhonin, V. P. ^{[1
,2
]}

机构：

[1] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia

[2] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia

[3] Sechenov Univ, IM Sechenov Moscow State Med Univ 1, Univ Clin Hosp, Minist Hlth Russian Federat, Moscow, Russia

[4] Moscow MV Lomonosov State Univ, Moscow, Russia

[5] Minist Hlth Russian Federat, EI Chazov Natl Med Res Ctr Cardiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 176卷 / 05期

关键词：

neurotrophin-3 (NT-3); brain-derived neurotrophic factor (BDNF); olfactory ensheathing cells; remyelination; spinal cord cysts; SCHWANN-CELLS; INJURY; REGENERATION; MYELINATION; SURVIVAL; DOMAIN;

D O I：

10.1007/s10517-024-06088-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.

引用

页码：666 / 671

页数：6

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