Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

被引:0
|
作者
Wun-Hao Cheng
Shih-Ya Kao
Chia-Ling Chen
Fara Silvia Yuliani
Lee-Yuan Lin
Chien-Huang Lin
Bing-Chang Chen
机构
[1] Taipei Medical University,School of Respiratory Therapy, College of Medicine
[2] Taipei Medical University,Respiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital
[3] Taipei Medical University,International Graduate Program in Medicine, College of Medicine
[4] Universitas Gadjah Mada,Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing
[5] Taipei Medical University,School of Medicine, Collage of Medicine
[6] Taipei Medical University,Gradual Institute of Medical Sciences, College of Medicine
[7] Taipei Medical University,Division of Thoracic Medicine, Department of Internal Medicine, School of Medicine, College of Medicine
来源
关键词
Severe asthma; Amphiregulin; TGF-β; CCN2; EMT; Airway fibrosis; EGF; EGFR;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] TGF-β1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling
    Phanish, MK
    Wahab, NA
    Hendry, BM
    Dockrell, MEC
    NEPHRON EXPERIMENTAL NEPHROLOGY, 2005, 100 (04): : E156 - E165
  • [42] Interleukin-2 induces extracellular matrix synthesis and TGF-β2 expression in retinal pigment epithelial cells
    Jing, Ruihua
    Qi, Tiantian
    Wen, Chan
    Yue, Jiaqi
    Wang, Guangyan
    Pei, Cheng
    Ma, Bo
    DEVELOPMENT GROWTH & DIFFERENTIATION, 2019, 61 (7-8) : 410 - 418
  • [43] Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-β1-Smad-dependent mechanism in human mesenchymal stem cells
    Moon, Hyun Jung
    Jeon, Eun Su
    Kim, Young Mi
    Lee, Mi Jeong
    Oh, Chang-Keun
    Kim, Jae Ho
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (06): : 1224 - 1234
  • [44] Tgf-β Induces Alveolar Epithelial Cell Apoptosis Through Activation Of A Fadd/caspase 8 Pathway
    Wheaton, A. K.
    Velikoff, M.
    Agarwal, M.
    Kim, K. K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [45] Dynamic analysis of the expression of the TGFβ/SMAD2 pathway and CCN2/CTGF during early steps of tooth development
    Pacheco, Marcos S.
    Reis, Alice H.
    Aguiar, Diego P.
    Lyons, Karen M.
    Abreu, Jose G.
    CELLS TISSUES ORGANS, 2008, 187 (03) : 199 - 210
  • [46] LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway
    Xue, Qingming
    Jiang, Hong
    Wang, Jinjie
    Wei, Dongshan
    CANADIAN RESPIRATORY JOURNAL, 2021, 2021
  • [47] ESSENTIAL ROLE OF CCN2 IN THE TGF-B PATHWAY REGULATION IN VASCULAR SMOOTH MUSCLE CELLS BY ENHANCING TGF-B RECEPTOR TYPE II EXPRESSION
    Tejera-Munoz, A.
    Marquez-Exposito, L.
    Tejedor-Santamaria, L.
    Rayego-Mateos, S.
    Orejudo, M.
    Suarez-Alvarez, B.
    Lopez-Larrea, C.
    Ruiz-Ortega, M.
    Rodrigues-Diez, R.
    ATHEROSCLEROSIS, 2022, 355 : E349 - E350
  • [48] Cell Cycle Arrest and CCN2 Expression in Proximal Tubular Epithelial Cells in a Mouse CKD Model
    Kosakai, Wakako
    Sato, Tetsuya
    Inoue, Tsutomu
    Fukaya, Daichi
    Amano, Hiroaki
    Okada, Hirokazu
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
  • [49] RETRACTED ARTICLE: Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway
    Liang Liu
    Xian Jin
    Cui-Fen Hu
    Ya-Ping Zhang
    Zhong’e Zhou
    Rong Li
    Cheng-Xing Shen
    Basic Research in Cardiology, 2018, 113
  • [50] TGF-β repression of Id2 induces apoptosis in gut epithelial cells
    Y Cao
    X Liu
    W Zhang
    X Deng
    H Zhang
    Y Liu
    L Chen
    E A Thompson
    C M Townsend
    T C Ko
    Oncogene, 2009, 28 : 1089 - 1098