Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

被引：0
|
作者：
Xinyuan Wang
Kimberly M. Christian
Hongjun Song
Guo-li Ming
机构：
[1] University of Pennsylvania,Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine
[2] Fudan University,School of Basic Medical Sciences
[3] University of Pennsylvania,Department of Cell and Developmental Biology, Perelman School of Medicine
[4] University of Pennsylvania,Institute for Regenerative Medicine, Perelman School of Medicine
[5] University of Pennsylvania,The Epigenetics Institute, Perelman School of Medicine
[6] University of Pennsylvania,Department of Psychiatry, Perelman School of Medicine
来源：
Genome Medicine | / 10卷
关键词：
Synaptic Dysfunction; Complex Psychiatric Disorders; Neuropsychiatric Diseases; Synaptic Pruning; Brain Organoids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
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