Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms

被引：38
|
作者：
Wang, Xinyuan [1 ,2 ,3 ]
Christian, Kimberly M. [1 ,2 ]
Song, Hongjun [1 ,2 ,4 ,5 ,6 ]
Ming, Guo-li [1 ,2 ,4 ,5 ,7 ]
机构：
[1] Univ Penn, Dept Neurosci, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Mahoney Inst Neurosci, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Fudan Univ, Sch Basic Med Sci, Shanghai 200040, Peoples R China
[4] Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Philadelphia, PA 19104 USA
[5] Univ Penn, Inst Regenerat Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[6] Univ Penn, Epigenet Inst, Perelman Sch Med, Philadelphia, PA 19104 USA
[7] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
GENOME MEDICINE | 2018年 / 10卷
基金：
美国国家卫生研究院;
关键词：
DYSREGULATION;
D O I：
10.1186/s13073-018-0518-5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
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页数：3
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