Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer

被引：0
|
作者：
M. V. Zinovyeva
L. G. Nikolaev
L. G. Kondratyeva
T. V. Vinogradova
E. D. Sverdlov
机构：
[1] Russian Academy of Sciences,Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
来源：
Doklady Biochemistry and Biophysics | 2018年 / 481卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mRNA content of the transcription factors KLF5 and ZEB1 was studied in pancreatic tumor tissues and in fetal and normal pancreas. Transcription of these factors was not high and similar in normal and fetal pancreatic tissues but greatly increased in the pancreatic ductal adenocarcinoma tissues. A significant positive correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues was observed.
引用
收藏
页码：219 / 221
页数：2
相关论文
共 50 条
  • [31] Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells
    Chen, CS
    Zhou, YF
    Zhou, ZM
    Sun, XD
    Otto, KB
    Uht, RM
    Dong, JT
    GENE, 2004, 330 : 133 - 142
  • [32] ZEB1 transcription factor induces tumor cell PD-L1 expression in melanoma
    Wirbel, Chloe
    Durand, Simon
    Boivin, Felix
    Plaschka, Maud
    Benboubker, Valentin
    Grimont, Maxime
    Barbollat-Boutrand, Laetitia
    Tondeur, Garance
    Balme, Brigitte
    Harou, Olivier
    Eberhardt, Anais
    Dalle, Stephane
    Lopez, Jonathan
    Caramel, Julie
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2025, 74 (04)
  • [33] Prognostic Significance of ZEB1 Expression in Cancer Cells and Cancer Associated Fibroblasts in Pancreatic Head Cancer
    Bronsert, Peter
    Kohler, Ilona
    Bausch, Dirk
    Werner, Martin
    Keck, Tobias
    Wellner, Ulrich F.
    GASTROENTEROLOGY, 2014, 146 (05) : S1090 - S1091
  • [34] The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers
    Spoelstra, NS
    Manning, NG
    Higashi, Y
    Darling, D
    Singh, M
    Shroyer, KR
    Broaddus, RR
    Horwitz, KB
    Richer, JK
    CANCER RESEARCH, 2006, 66 (07) : 3893 - 3902
  • [35] Significance of the Transcription Factor Klf5 In Myocardial Hypertrophy In Response to Pressure Overload
    Takeda, Norifumi
    Manabe, Ichiro
    Uchino, Yuichi
    Nagai, Ryozo
    CIRCULATION, 2008, 118 (18) : S431 - S431
  • [36] Overexpressing PRMT1 Inhibits Proliferation and Invasion in Pancreatic Cancer by Inverse Correlation of ZEB1
    Lin, Zhibin
    Chen, Yao
    Lin, Zhaoxian
    Chen, Chunshan
    Dong, Yangyang
    IUBMB LIFE, 2018, 70 (10) : 1032 - 1039
  • [37] Identification of a transcriptional repressor of the transcription factor KLF5/BTEB2
    Suzuki, T
    Miyamoto, S
    Aizawa, K
    Muto, S
    Horikoshi, M
    Nagai, R
    CIRCULATION, 2002, 106 (19) : 165 - 166
  • [38] Astrocyte-specific gene targets of the transcription factor ZEB1
    Singh, N.
    Zhou, Y.
    Martinez-Garay, I.
    Siebzehnrubl, F. A.
    GLIA, 2023, 71 : E414 - E414
  • [39] HYPERMETHYLATION OF THE GENE FOR THE TRANSCRIPTION FACTOR KLF5 IS ASSOCIATED WITH POOR PROGNOSIS IN AML
    Diakiw, S.
    Brown, A.
    Kok, C.
    To, B.
    Lewis, I.
    D'Andrea, R.
    EXPERIMENTAL HEMATOLOGY, 2011, 39 (08) : S82 - S82
  • [40] The transcription factor ZNF248 promotes colorectal cancer metastasis by binding to ZEB1
    Ren, Yanying
    Sun, Xiaoxu
    Chen, Xin
    Shao, Shuai
    Tang, JingTong
    Xu, Zhaohui
    Xu, Yang
    Kang, Haonan
    Wang, Liming
    JOURNAL OF CANCER, 2024, 15 (16): : 5440 - 5450
12345