Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

被引：0
|
作者：
T. G. Razina
E. P. Zueva
A. V. Ulrich
O. Yu. Rybalkina
A. V. Chaikovskii
N. V. Isaikina
G. I. Kalinkina
V. V. Zhdanov
G. N. Zyuz’kov
机构：
[1] E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine,
[2] Siberian State Medical University,undefined
[3] Ministry of Health of the Russian Federation,undefined
[4] National Research Tomsk State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 162卷
关键词：
Lewis lung carcinoma; B-16 melanoma; tumor stem cells; Fructus Sorbi aucupariae; anthocyans;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
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页码：93 / 97
页数：4
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