The chemo- enzymatic synthesis of labeled l-amino acids and some of their derivatives

被引：0

作者：

Małgorzata Pająk

Katarzyna Pałka

Elżbieta Winnicka

Marianna Kańska

机构：

[1] Warsaw University,Department of Chemistry

[2] Medical University of Warsaw,Department of Biochemistry, 2nd Faculty of Medicine

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2018年 / 317卷

关键词：

Amino acid; Bioamine; Deuterium; Enzyme; Labeling; Tritium;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) specifically labeled with carbon and hydrogen isotopes, which were elaborated in our research group by the past 20 years. These compounds could be then employed to characterize the mechanisms of enzymatic reactions via kinetic and solvent isotope effects methods.

引用

页码：643 / 666

页数：23

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