Increasing the solubility of phenazepam by forming solid dispersions

被引：0
|
作者：
I. I. Krasnyuk
O. V. Manakhova
R. U. Khabriev
V. A. Popkov
V. Yu. Reshetnyak
O. I. Krasnyuk
机构：
[1] Sechenov Moscow Medical Academy,
来源：
Pharmaceutical Chemistry Journal | 2010年 / 44卷
关键词：
solid dispersion; solubility; phenazepam; poly(ethyleneglycol)-1500; poly(vinylpyrrolidone)-10000; β-cyclodextrin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of solid dispersion (SD) formation on the solubility of phenazepam has been studied. Phenazepam and its SDs with poly(ethyleneglycol)-1500 (PEG), poly(vinylpyrrolidone)-10000 (PVP), and β-cyclodextrin were studied. The SD with PVP increases both the solubility and the dissolution rate of phenazepam. Results obtained by a complex of physical and chemical methods suggest that the improved release of phenazepam from the SD with PVP is due to solubilization, amorphization, and formation of a colloidal dispersion of the parent drug substance.
引用
收藏
页码：274 / 277
页数：3
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