Chiral ligand-exchange chromatography on an RP HPLC column coated with a new chiral selector derived froml-spinacine

被引：0
|
作者：
M. Remelli
D. Trombin
C. Conato
机构：
[1] University of Ferrara,Department of Chemistry
来源：
Chromatographia | 2002年 / 55卷
关键词：
Column liquid chromatography; Chiral separations; Ligand exchange; -; -decyl-; -spinacine; Amino acids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A commercial reversed-phase (RP) C18 HPLC column has been dynamically coated with the chiral selectorNτ-n-decyl-l-spinacine and then loaded with copper(II) ions. Several racemic mixtures of underivatized amino acids and oligopeptides were resolved on the column by chiral ligand-exchange chromatography. The most important experimental conditions affecting column efficiency, retention, and selectivity (temperature and mobile phase flow rate and composition) were extensively investigated.
引用
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页码：301 / 306
页数：5
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