In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic

被引：0
|
作者：
T. A. Antipova
T. A. Gudasheva
S. B. Seredenin
机构：
[1] V. V. Zakusov Institute of Pharmacology,
[2] Russian Academy of Medical Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 150卷
关键词：
neuroprotection; GK-2; oxidative stress; glutamate toxicity; MPTP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10−9 M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H2O2 and glutamate. GK-2 in a concentration of 10−8 M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.
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页码：607 / 609
页数：2
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