In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic

被引：0
|
作者：
T. A. Antipova
T. A. Gudasheva
S. B. Seredenin
机构：
[1] V. V. Zakusov Institute of Pharmacology,
[2] Russian Academy of Medical Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 150卷
关键词：
neuroprotection; GK-2; oxidative stress; glutamate toxicity; MPTP;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a concentration of up to 10−9 M produced a protective effect on the culture of immortalized mouse hippocampal neurons (line HT-22) after addition of H2O2 and glutamate. GK-2 in a concentration of 10−8 M protected rat PC-12 pheochromocytoma cells from the neurotoxin MPTP. The neuroprotective effect of this peptide on the model of oxidative stress was also observed in the primary culture of embryonic rat hippocampal neurons.
引用
收藏
页码：607 / 609
页数：2
相关论文
共 50 条
  • [1] In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic
    Antipova, T. A.
    Gudasheva, T. A.
    Seredenin, S. B.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 150 (05) : 607 - 609
  • [2] Synthesis of GK-2, a Dimeric Dipeptide Nerve Growth Factor Mimetic and Potential Neuroprotective Agent
    Sazonova, N. M.
    Tarasyuk, A. V.
    Kurilov, D. V.
    Pomogaibo, S. V.
    Gudasheva, T. A.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (07) : 439 - 448
  • [3] Synthesis of GK-2, a Dimeric Dipeptide Nerve Growth Factor Mimetic and Potential Neuroprotective Agent
    N. M. Sazonova
    A. V. Tarasyuk
    D. V. Kurilov
    S. V. Pomogaibo
    T. A. Gudasheva
    [J]. Pharmaceutical Chemistry Journal, 2015, 49 : 439 - 448
  • [4] Antiparkinsonian Properties of a Nerve Growth Factor Dipeptide Mimetic GK-2 in in Vivo Experiments
    Povarnina, P. Yu.
    Gudasheva, T. A.
    Vorontsova, O. N.
    Bondarenko, N. A.
    Seredenin, S. B.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (06) : 690 - 693
  • [5] Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats
    V. A. Kraineva
    T. A. Gudasheva
    S. O. Kotelnikova
    T. A. Antipova
    S. B. Seredenin
    [J]. Bulletin of Experimental Biology and Medicine, 2013, 154 : 642 - 644
  • [6] Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats
    Kraineva, V. A.
    Gudasheva, T. A.
    Kotelnikova, S. O.
    Antipova, T. A.
    Seredenin, S. B.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 154 (05) : 642 - 644
  • [7] Antiparkinsonian Properties of a Nerve Growth Factor Dipeptide Mimetic GK-2 in in Vivo Experiments
    P. Yu. Povarnina
    T. A. Gudasheva
    O. N. Vorontsova
    N. A. Bondarenko
    S. B. Seredenin
    [J]. Bulletin of Experimental Biology and Medicine, 2011, 151 : 690 - 693
  • [8] Synthesis and In Vitro Neuroprotective Activity of Analogs with Various Spacer Lengths of a Dimeric Dipeptide Mimetic (GK-2) of Nerve Growth Factor
    A. V. Tarasyuk
    N. M. Sazonova
    D. V. Kurilov
    A. A. Lubin
    T. A. Antipova
    T. A. Gudasheva
    [J]. Pharmaceutical Chemistry Journal, 2019, 53 : 487 - 494
  • [9] Synthesis and In Vitro Neuroprotective Activity of Analogs with Various Spacer Lengths of a Dimeric Dipeptide Mimetic (GK-2) of Nerve Growth Factor
    Tarasyuk, A., V
    Sazonova, N. M.
    Kurilov, D., V
    Lubin, A. A.
    Antipova, T. A.
    Gudasheva, T. A.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (06) : 487 - 494
  • [10] Synthesis and In Vitro Neuroprotector Activity of Diastereoisomers of a Dimeric Dipeptide Mimetic of Nerve Growth Factor GK-2
    N. M. Sazonova
    A. V. Tarasyuk
    A. N. Shumskii
    A. G. Rebeko
    P. I. Antipov
    I. O. Logvinov
    T. A. Antipova
    T. A. Gudasheva
    [J]. Pharmaceutical Chemistry Journal, 2018, 52 : 704 - 710
12345