Role of supraspinal tachykinins for micturition in conscious rats with and without bladder outlet obstruction

被引:0
|
作者
B.J. Gu
O. Ishizuka
Y. Igawa
O. Nishizawa
K.-E. Andersson
机构
[1] Department of Urology,
[2] Shinshu University School of Medicine,undefined
[3] Asahi 3-1-1,undefined
[4] Matsumoto 390-8621,undefined
[5] Japan,undefined
[6] Department of Clinical Pharmacology,undefined
[7] Lund University Hospital,undefined
[8] Lund,undefined
[9] Sweden,undefined
关键词
NK-receptors Bladder hyperactivity Micturition reflex Urinary incontinence;
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中图分类号
学科分类号
摘要
In order to clarify the role of supraspinal tachykinins in volume-induced micturition and in bladder hyperactivity secondary to bladder outlet obstruction, conscious, normal, female Sprague-Dawley rats were investigated cystometrically before and after intracerebroventricular administration of RP 67,580, a selective antagonist of neurokinin (NK)-1 receptors and/or SR 48,968, a selective antagonist of NK-2 receptors.
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页码:543 / 548
页数:5
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