Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

被引:0
|
作者
Patrick S. Costello
Maighread Gallagher
Doreen A. Cantrell
机构
[1] Lymphocyte Activation Laboratory,
[2] Cancer Research UK London Research Institute,undefined
[3] Lincoln's Inn Fields Laboratories,undefined
来源
Nature Immunology | 2002年 / 3卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
T cell activation is triggered by several hours of contact with peptide–major histocompatibility (MHC) complexes on the surface of antigen-presenting cells (APCs). The nature and location of the sustained signal transduction pathways required for T cell activation are unknown. We show here that the production of phosphatidylinositol(3,4,5)triphosphate (PIP3) was dynamically sustained for hours as T cells responded to antigen. In addition, sustained elevation of PIP3 was essential for T cell proliferation. There was PIP3 accumulation in the T cell–APC contact zone and at the antipodal pole of the cell. The immune synapse is thus not the sole site of sustained signal transduction in activated T cells.
引用
收藏
页码:1082 / 1089
页数:7
相关论文
共 50 条
  • [1] Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
    Costello, PS
    Gallagher, M
    Cantrell, DA
    [J]. NATURE IMMUNOLOGY, 2002, 3 (11) : 1082 - 1089
  • [2] Lipid switches in the immunological synapse
    Griffiths, Gillian
    Brügger, Britta
    Freund, Christian
    [J]. Journal of Biological Chemistry, 2024, 300 (07)
  • [3] A dynamic view of the immunological synapse
    Dustin, ML
    [J]. SEMINARS IN IMMUNOLOGY, 2005, 17 (06) : 400 - 410
  • [4] Mobilization of lipid raft at immunological synapse
    Hashimoto-Tane, Akiko
    Yokosuka, Tadashi
    Ishihara, Chitose
    Saito, Takashi
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 102P - 102P
  • [5] Integrin inside-out signaling and the immunological synapse
    Springer, Timothy A.
    Dustin, Michael L.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2012, 24 (01) : 107 - 115
  • [6] Molecular topography of a dynamic immunological synapse
    Storim, O. Julian
    Geissler, Eva
    Kretzschmar, Martin
    Broecker, Eva-B.
    Friedl, Peter
    [J]. CELL STRUCTURE AND FUNCTION, 2004, 29 : 30 - 30
  • [7] Lipid-based patterning of the immunological synapse
    Huse, Morgan
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2014, 42 : 1506 - 1511
  • [8] The Immunological Synapse: a Dynamic Platform for Local Signaling
    Krummel, Matthew F.
    Cahalan, Michael D.
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (03) : 364 - 372
  • [9] The Immunological Synapse: a Dynamic Platform for Local Signaling
    Matthew F. Krummel
    Michael D. Cahalan
    [J]. Journal of Clinical Immunology, 2010, 30 : 364 - 372
  • [10] Formation of the CTL immunological synapse is regulated by lipid rafts
    Marwali, MR
    Muzia, D
    MacLeod, M
    Takei, F
    [J]. FASEB JOURNAL, 2004, 18 (04): : A428 - A428