Lipid-based patterning of the immunological synapse

被引：11
|
作者：
Huse, Morgan [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2014年 / 42卷
基金：
美国国家卫生研究院;
关键词：
actin; cell polarity; microtubule; protein kinase C (PKC); signal transduction; T-cell; PROTEIN-KINASE-C; T-CELL-ACTIVATION; MICROTUBULE-ORGANIZING CENTER; PKC-THETA; CYTOSKELETAL REORGANIZATION; LYMPHOCYTE DIVISION; ACTIN CYTOSKELETON; MYOSIN-II; TGF-BETA; POLARIZATION;
D O I：
10.1042/BST20140191
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The immunological synapse controls T-lymphocyte function by polarizing effector responses towards the antigen-presenting cell. In this review, I discuss the molecular pathways required for synapse assembly, focusing on the central roles played by lipid second-messenger signalling.
引用
收藏
页码：1506 / 1511
页数：6
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